Limbic irritability and chaotic neural response during
conflicting Stroop task in the patients with unipolar
depression

J 2006

Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression

BOB, Petr and Marek ŠUSTA

Basic information

Original name

Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression

Name in Czech

Limbická iritabilita a chaotická neuronová odezva v průběhu konfliktního Stroopova testu u pacientů s unipolární depresí

Authors

BOB, Petr (203 Czech Republic) and Marek ŠUSTA (203 Czech Republic, guarantor)

Edition

Physiological Research, 2006, 0862-8408

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.093

Organization unit

Faculty of Social Studies

UT WoS

000243996600012

Keywords in English

Depression; Stress; Limbic irritability; HRV; Lyapunov exponent; Chaos; Anticonvulsants

Abstract

V originále

According to recent findings activation of anterior cingulate cortex (ACC) is related to detecting cognitive conflict. This conflict related activation elicits autonomic responses which can be assessed by psychophysiological measures such as heart rate variability calculated as beat to beat R-R intervals (RRI). Recent findings in neuroscience also suggest that cognitive conflict is related to specific nonlinear chaotic changes of the signal generated by neural systems. The present study used Stroop word-colour test as an experimental approach to psychophysiological study of cognitive conflict in connection with RRI measurement, psychometric measurement of limbic irritability (LSCL-33), depression (BDI-II) and calculation of largest Lyapunov exponents in nonlinear data analysis of RRI time series. Significant correlation 0.61 between largest Lyapunov exponents and LSCL-33 found in this study indicate that a defect of neural inhibition during conflicting Stroop task is closely related to limbic irritability. Because limbic irritability is probably closely related to epileptiform abnormalities in the temporo-limbic structures, this result might represent useful instrument for indication of anticonvulsant treatment in depressive patients who are resistant to antidepressant medication.

Links

1M06039, research and development project

Name: Centrum pro neuropsychiatrický výzkum traumatického stresu

Investor: Ministry of Education, Youth and Sports of the CR

Citovat

BOB, Petr and Marek ŠUSTA. Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression. Physiological Research. 2006, vol. 55, No 1. ISSN 0862-8408.

@article{706195,
   author = {Bob, Petr and Šusta, Marek},
   article_number = {1},
   keywords = {Depression; Stress; Limbic irritability; HRV; Lyapunov exponent; Chaos; Anticonvulsants},
   language = {eng},
   issn = {0862-8408},
   journal = {Physiological Research},
   title = {Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression},
   volume = {55},
   year = {2006}
}

TY  - JOUR
ID  - 706195
AU  - Bob, Petr - Šusta, Marek
PY  - 2006
TI  - Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression
JF  - Physiological Research
VL  - 55
IS  - 1
SN  - 08628408
KW  - Depression
KW  - Stress
KW  - Limbic irritability
KW  - HRV
KW  - Lyapunov exponent
KW  - Chaos
KW  - Anticonvulsants
N2  - According to recent findings activation of anterior cingulate cortex (ACC) is related to detecting cognitive conflict. This conflict related activation elicits autonomic responses which can be assessed by psychophysiological measures such as heart rate variability calculated as beat to beat R-R intervals (RRI). Recent findings in neuroscience also suggest that cognitive conflict is related to specific nonlinear chaotic changes of the signal generated by neural systems. The present study used Stroop word-colour test as an experimental approach to psychophysiological study of cognitive conflict in connection with RRI measurement, psychometric measurement of limbic irritability (LSCL-33), depression (BDI-II) and calculation of largest Lyapunov exponents in nonlinear data analysis of RRI time series. Significant correlation 0.61 between largest Lyapunov exponents and LSCL-33 found in this study indicate that a defect of neural inhibition during conflicting Stroop task is closely related to limbic irritability. Because limbic irritability is probably closely related to epileptiform abnormalities in the temporo-limbic structures, this result might represent useful instrument for indication of anticonvulsant treatment in depressive patients who are resistant to antidepressant medication.
ER  -

BOB, Petr and Marek ŠUSTA. Limbic irritability and chaotic neural response during conflicting Stroop task in the patients with unipolar depression. \textit{Physiological Research}. 2006, vol.~55, No~1. ISSN~0862-8408.

Detailed Information on Publication Record