J 2006

MicroRNA BIOGENESIS, FUNCTIONALITY AND CANCER RELEVANCE

KUSENDA, Branislav, Marek MRÁZ, Jiří MAYER and Šárka POSPÍŠILOVÁ

Basic information

Original name

MicroRNA BIOGENESIS, FUNCTIONALITY AND CANCER RELEVANCE

Name in Czech

MicroRNA BIOGENESIS, FUNCTIONALITY AND CANCER RELEVANCE

Name (in English)

MicroRNA BIOGENESIS, FUNCTIONALITY AND CANCER RELEVANCE

Authors

KUSENDA, Branislav, Marek MRÁZ, Jiří MAYER and Šárka POSPÍŠILOVÁ

Edition

Biomedical Papers, 2006, 1213-811

Other information

Type of outcome

Článek v odborném periodiku

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

Organization unit

Faculty of Science

Keywords in English

microRNA;miRNA;RNA interference;RNAi;cancer;CLL;chronická lymfatická leukémie

Tags

Tags

Reviewed
Změněno: 30/12/2006 23:05, prof. MUDr. Mgr. Marek Mráz, Ph.D.

Abstract

V originále

Background: MicroRNAs (miRNA) are small non–coding RNAs that negatively regulate gene expression in a sequence– specific manner. Post–transcriptional silencing of target genes by miRNA occurs either by specific cleavage of homologous mRNA or by specific inhibition of protein synthesis. MiRNAs are essential regulators of various processes such as proliferation, differentiation, development, cell death and interaction between virus and host cell. Aim: The aim of this paper is to summarize the main findings from research on miRNA biogenesis, functionality and cancer relevance. Method: A narrative literature review of all of the relevant papers known to the authors was conducted. Results: Several human diseases including cancer are associated with aberrant regulation of miRNAs expression or deficiency in miRNA biogenesis. Analysis of miRNA expression signatures can serve as a valuable tool for cancer classification, diagnostics and prediction of tumor behavior. Conclusions: There has been demonstrated a possibility to use these microRNA signatures for a specific cancer classification with potential predictive and therapeutic value. The known data provide evidence that microRNAs may open new ways for cancer diagnosis, prognosis estimation and therapy.