KAŠPÁREK, Tomáš, Radovan PŘIKRYL, Michal MIKL, Daniel SCHWARZ, Eva ČEŠKOVÁ and Petr KRUPA. Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia. Progress in Neuro-Psychopharmacology and Biological Psychiatry. Elsevier, 2007, vol. 2007, No 31, p. 151-157. ISSN 0278-5846.
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Basic information
Original name Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
Name in Czech Prefrontální, ne však temporální, změny šedé hmoty u mužů s první epizodou schizofrenie
Name (in English) Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
Authors KAŠPÁREK, Tomáš (203 Czech Republic, guarantor), Radovan PŘIKRYL (203 Czech Republic), Michal MIKL (203 Czech Republic), Daniel SCHWARZ (203 Czech Republic), Eva ČEŠKOVÁ (203 Czech Republic) and Petr KRUPA (203 Czech Republic).
Edition Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2007, 0278-5846.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
WWW URL
Impact factor Impact factor: 2.802
RIV identification code RIV/00216224:14110/07:00021809
Organization unit Faculty of Medicine
UT WoS 000243738000021
Keywords in English first-episode; optimized voxel-based morphometry; prefrontal cortex; schizophrenia
Tags first-episode, optimized voxel-based morphometry, prefrontal cortex, schizophrenia
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Eva Češková, CSc., učo 726. Changed: 19/6/2009 14:15.
Abstract
Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.
Abstract (in English)
Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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