Detailed Information on Publication Record
2007
Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
KAŠPÁREK, Tomáš, Radovan PŘIKRYL, Michal MIKL, Daniel SCHWARZ, Eva ČEŠKOVÁ et. al.Basic information
Original name
Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
Name in Czech
Prefrontální, ne však temporální, změny šedé hmoty u mužů s první epizodou schizofrenie
Name (in English)
Prefrontal but not temporal gray matter changes in males with first-episode schizophrenia
Authors
KAŠPÁREK, Tomáš (203 Czech Republic, guarantor), Radovan PŘIKRYL (203 Czech Republic), Michal MIKL (203 Czech Republic), Daniel SCHWARZ (203 Czech Republic), Eva ČEŠKOVÁ (203 Czech Republic) and Petr KRUPA (203 Czech Republic)
Edition
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Elsevier, 2007, 0278-5846
Other information
Language
Czech
Type of outcome
Článek v odborném periodiku
Field of Study
30000 3. Medical and Health Sciences
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
References:
Impact factor
Impact factor: 2.802
RIV identification code
RIV/00216224:14110/07:00021809
Organization unit
Faculty of Medicine
UT WoS
000243738000021
Keywords in English
first-episode; optimized voxel-based morphometry; prefrontal cortex; schizophrenia
Tags
International impact, Reviewed
Změněno: 19/6/2009 14:15, prof. MUDr. Eva Češková, CSc.
V originále
Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.
In English
Objectives of the study was to investigate regional gray matter changes in the first-episode schizophrenia patients. We used optimized voxel-based morphometry in 22 first-episode schizophrenia patients and 18 healthy controls of comparable age, gender and handedness. The first episode group had significantly reduced gray matter volume in the prefrontal cortex (inferior and middle prefrontal gyrus, cingulate gyrus). We identified no differences in temporal cortex. Our data support the theoretical assumption that prefrontal dysfunction underlines the primary pathology and clinical manifestation of schizophrenia. We are inclined to explain the differences in the pattern of morphological changes reported in other first-episode studies - especially the lack of changes in the temporal cortex - by heterogenity of schizophrenia, potential progression and antipsychotic medication effect.
Links
| MSM0021622404, plan (intention) |
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