J 2007

Acetylcholinesterases - the similarities and differences

WIESNER, Jiří, Zdeněk KŘÍŽ, Kamil KUČA, Daniel JUN, Jaroslav KOČA et. al.

Basic information

Original name

Acetylcholinesterases - the similarities and differences

Name in Czech

Acetylcholinesterasy - podobnosti a rozdily

Authors

WIESNER, Jiří (203 Czech Republic, guarantor), Zdeněk KŘÍŽ (203 Czech Republic), Kamil KUČA (203 Czech Republic), Daniel JUN (203 Czech Republic) and Jaroslav KOČA (203 Czech Republic)

Edition

Journal of Enzyme Inhibition and Medicinal Chemistry, UK, Taylor & Francis, 2007, 1475-6366

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10403 Physical chemistry

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.343

RIV identification code

RIV/00216224:14310/07:00020104

Organization unit

Faculty of Science

UT WoS

000248489700005

Keywords in English

computational chemistry;computer modeling;acetycholinesterase;AChE;species;alignment

Tags

Tags

Reviewed
Změněno: 8/11/2007 12:46, Mgr. Zdeněk Kříž, Ph.D.

Abstract

ORIG CZ

V originále

Acetylcholinesterase (AChE) is a widely spread enzyme playing a very important role in nerve signal transmission. There are several reasons as to why this enzyme is studied, one of them is the treatment of Alzheimers disease. As AChE controls key processes, its inhibition leads to the very fast death of an organism, including humans. However, when this feature is to be used for killing of unwanted organisms (like mosquitoes), one is faced with the question - how much does AChEs differ between species and what are the differences? In this article, the structural point of view was utilized to answer the above questions. The various primary and tertiary alignments show that AChEs are very evolutionary conserved enzymes and this fact leads to difficulties in the search for inhibitors specific for a particular species.

In Czech

Srovnavaci studie acetylcholinesteras ruznych zivocisnych druhu.

Links

GD204/03/H016, research and development project
Name: Strukturní biofyzika makromolekul
Investor: Czech Science Foundation, Structural biophysics of macromolecules
LC06030, research and development project
Name: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
MSM0021622413, plan (intention)
Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment