Blood Pressure and Baroreflex Sensitivity after Anthracycline
Chemotherapy in Childhood with Respect to Fatty Acid Metabolism

J 2005

Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism

ZÁVODNÁ, Eva, Hana HRSTKOVÁ, Pavla BALCÁRKOVÁ, Zuzana NOVÁKOVÁ, Nataša HONZÍKOVÁ et. al.

Basic information

Original name

Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism

Name in Czech

Krevní tlak a citlivost baroreflexu u dětí a adolescentů po chemoterapii antracykliny vzhledem k metabolismu lipidů

Authors

ZÁVODNÁ, Eva (203 Czech Republic, guarantor), Hana HRSTKOVÁ (203 Czech Republic), Pavla BALCÁRKOVÁ (203 Czech Republic), Zuzana NOVÁKOVÁ (203 Czech Republic), Nataša HONZÍKOVÁ (203 Czech Republic) and Bohumil FIŠER (203 Czech Republic)

Edition

Scripta medica, Brno, Masarykova univerzita, Lékařská fakulta, 2005, 1211-3395

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30105 Physiology

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14110/05:00019033

Organization unit

Faculty of Medicine

Keywords (in Czech)

Antracyklin, krevní tlak, baroreflex, variabilita srdeční frekvence, cholesterol

Keywords in English

Anthracycline; Blood pressure; Baroreflex sensitivity; Heart rate variability; Cholesterol

Abstract

ORIG CZ

V originále

Late effects of caardiotoxic therapy on childhood cancer were studied. Body and circulation parameters were compared in 206 helathy controls, and 97 children and adolescents after antitumour treatment at the age of 11 - 21 years with respect to plasma lipid level. The subjects after antitumour therapy had increased parasympathetic and decreased sympathetic tonic activity together with decreased baroreflex sensitivity. The increase of inter-beat interval variability was neither the result of a primary increase of vasomotor activity nor an increase of baroreflex sensitivity response to changes in blood pressure. We can explain it by increasing parasympathetic control of the heart. The circulatory changes did not bear on obesity, but they were rather a specific effect of tumour disease and antitumou treatment.

In Czech

Studovali jsme pozdní efekt kardiotoxické terapie dětských nádorových onemocnění. Dětští pacienti po prodělané protinádorové léčbě měli zvýšenou parasympatickou a sníženou sympatickou aktivitu spojenou se sníženou citlivostí baroreflexu.

Links

NR8006, research and development project

Name: Autonomní oběhové funkce, funkce myokardu a kardiorespirační funkce u dětí a adolescentů po léčbě zhoubného nádoru

Investor: Ministry of Health of the CR

Citovat

ZÁVODNÁ, Eva, Hana HRSTKOVÁ, Pavla BALCÁRKOVÁ, Zuzana NOVÁKOVÁ, Nataša HONZÍKOVÁ and Bohumil FIŠER. Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism. Scripta medica. Brno: Masarykova univerzita, Lékařská fakulta, 2005, vol. 78, No 5, p. 257-263. ISSN 1211-3395.

@article{708167,
   author = {Závodná, Eva and Hrstková, Hana and Balcárková, Pavla and Nováková, Zuzana and Honzíková, Nataša and Fišer, Bohumil},
   article_location = {Brno},
   article_number = {5},
   keywords = {Anthracycline; Blood pressure; Baroreflex sensitivity; Heart rate variability; Cholesterol},
   language = {eng},
   issn = {1211-3395},
   journal = {Scripta medica},
   title = {Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism},
   volume = {78},
   year = {2005}
}

TY  - JOUR
ID  - 708167
AU  - Závodná, Eva - Hrstková, Hana - Balcárková, Pavla - Nováková, Zuzana - Honzíková, Nataša - Fišer, Bohumil
PY  - 2005
TI  - Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism
JF  - Scripta medica
VL  - 78
IS  - 5
SP  - 257-263
EP  - 257-263
PB  - Masarykova univerzita, Lékařská fakulta
SN  - 12113395
KW  - Anthracycline
KW  - Blood pressure
KW  - Baroreflex sensitivity
KW  - Heart rate variability
KW  - Cholesterol
N2  - Late effects of caardiotoxic therapy on childhood cancer were studied. Body and circulation parameters were compared in 206 helathy controls, and 97 children and adolescents after antitumour treatment at the age of 11 - 21 years with respect to plasma lipid level. The subjects after antitumour therapy had increased parasympathetic and decreased sympathetic tonic activity together with decreased baroreflex sensitivity. The increase of inter-beat interval variability was neither the result of a primary increase of vasomotor activity nor an increase of baroreflex sensitivity response to changes in blood pressure. We can explain it by increasing parasympathetic control of the heart. The circulatory changes did not bear on obesity, but they were rather a specific effect of tumour disease and antitumou treatment.
ER  -

ZÁVODNÁ, Eva, Hana HRSTKOVÁ, Pavla BALCÁRKOVÁ, Zuzana NOVÁKOVÁ, Nataša HONZÍKOVÁ and Bohumil FIŠER. Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism. \textit{Scripta medica}. Brno: Masarykova univerzita, Lékařská fakulta, 2005, vol.~78, No~5, p.~257-263. ISSN~1211-3395.

Detailed Information on Publication Record