ZÁVODNÁ, Eva, Hana HRSTKOVÁ, Pavla BALCÁRKOVÁ, Zuzana NOVÁKOVÁ, Nataša HONZÍKOVÁ and Bohumil FIŠER. Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism. Scripta medica. Brno: Masarykova univerzita, Lékařská fakulta, 2005, vol. 78, No 5, p. 257-263. ISSN 1211-3395.
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Basic information
Original name Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism
Name in Czech Krevní tlak a citlivost baroreflexu u dětí a adolescentů po chemoterapii antracykliny vzhledem k metabolismu lipidů
Authors ZÁVODNÁ, Eva (203 Czech Republic, guarantor), Hana HRSTKOVÁ (203 Czech Republic), Pavla BALCÁRKOVÁ (203 Czech Republic), Zuzana NOVÁKOVÁ (203 Czech Republic), Nataša HONZÍKOVÁ (203 Czech Republic) and Bohumil FIŠER (203 Czech Republic).
Edition Scripta medica, Brno, Masarykova univerzita, Lékařská fakulta, 2005, 1211-3395.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30105 Physiology
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/05:00019033
Organization unit Faculty of Medicine
Keywords (in Czech) Antracyklin, krevní tlak, baroreflex, variabilita srdeční frekvence, cholesterol
Keywords in English Anthracycline; Blood pressure; Baroreflex sensitivity; Heart rate variability; Cholesterol
Tags anthracycline, baroreflex sensitivity, Blood pressure, Cholesterol, heart rate variability
Changed by Changed by: prof. MUDr. Bohumil Fišer, CSc., učo 2725. Changed: 19/6/2009 12:18.
Abstract
Late effects of caardiotoxic therapy on childhood cancer were studied. Body and circulation parameters were compared in 206 helathy controls, and 97 children and adolescents after antitumour treatment at the age of 11 - 21 years with respect to plasma lipid level. The subjects after antitumour therapy had increased parasympathetic and decreased sympathetic tonic activity together with decreased baroreflex sensitivity. The increase of inter-beat interval variability was neither the result of a primary increase of vasomotor activity nor an increase of baroreflex sensitivity response to changes in blood pressure. We can explain it by increasing parasympathetic control of the heart. The circulatory changes did not bear on obesity, but they were rather a specific effect of tumour disease and antitumou treatment.
Abstract (in Czech)
Studovali jsme pozdní efekt kardiotoxické terapie dětských nádorových onemocnění. Dětští pacienti po prodělané protinádorové léčbě měli zvýšenou parasympatickou a sníženou sympatickou aktivitu spojenou se sníženou citlivostí baroreflexu.
Links
NR8006, research and development projectName: Autonomní oběhové funkce, funkce myokardu a kardiorespirační funkce u dětí a adolescentů po léčbě zhoubného nádoru
Investor: Ministry of Health of the CR
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