VAŇHARA, Petr, Vítězslav BRYJA, Viktor HORVÁTH, Alois KOZUBÍK, Aleš HAMPL a Jan ŠMARDA. c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2. Biochemical and Biophysical Research Communications. San Diego (USA): Academic Press, 2007, roč. 353, č. 1, s. 92-97. ISSN 0006-291X. |
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@article{709431, author = {Vaňhara, Petr and Bryja, Vítězslav and Horváth, Viktor and Kozubík, Alois and Hampl, Aleš and Šmarda, Jan}, article_location = {San Diego (USA)}, article_number = {1}, keywords = {Jun; cyclin A; CDK2; apoptosis; v-myb-transformed monoblasts}, language = {eng}, issn = {0006-291X}, journal = {Biochemical and Biophysical Research Communications}, title = {c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2}, volume = {353}, year = {2007} }
TY - JOUR ID - 709431 AU - Vaňhara, Petr - Bryja, Vítězslav - Horváth, Viktor - Kozubík, Alois - Hampl, Aleš - Šmarda, Jan PY - 2007 TI - c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2 JF - Biochemical and Biophysical Research Communications VL - 353 IS - 1 SP - 92-97 EP - 92-97 PB - Academic Press SN - 0006291X KW - Jun KW - cyclin A KW - CDK2 KW - apoptosis KW - v-myb-transformed monoblasts N2 - c-Jun is one of the major components of the Activating Protein-1 (AP-1), the transcription factor that participates in regulation of proliferation, differentiation and apoptosis. In this study, we explored functional interactions of the c-Jun protein with several regulators of the G1/S transition in serum-deprived v-myb-transformed chicken monoblasts BM2. We show that the c-Jun protein induces expression of cyclin A, thus up-regulating activity of cyclin A-associated cyclin-dependent kinase 2 (CDK2), and causing massive programmed cell death of starved BM2cJUN cells. Specific inhibition of CDK2 suppresses frequency of apoptosis of BM2cJUN cells. We conclude that up-regulation of cyclin A-expression and CDK2 activity can represent important link between the c-Jun protein, cell cycle machinery and programmed cell death pathway in leukemic cells. ER -
VAŇHARA, Petr, Vítězslav BRYJA, Viktor HORVÁTH, Alois KOZUBÍK, Aleš HAMPL a Jan ŠMARDA. c-Jun induces apoptosis of starved BM2 monoblasts by activating cyclin A-CDK2. \textit{Biochemical and Biophysical Research Communications}. San Diego (USA): Academic Press, 2007, roč.~353, č.~1, s.~92-97. ISSN~0006-291X.
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