NAVRÁTILOVÁ, Jarmila, Viktor HORVÁTH, Alois KOZUBÍK, Antonín LOJEK, Joseph LIPSICK and Jan ŠMARDA. p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts. Differentiation. Malden, USA: Blackwell Publishing, 2007, vol. 75, No 7, p. 592-604. ISSN 0301-4681. |
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@article{710231, author = {Navrátilová, Jarmila and Horváth, Viktor and Kozubík, Alois and Lojek, Antonín and Lipsick, Joseph and Šmarda, Jan}, article_location = {Malden, USA}, article_number = {7}, keywords = {p53; differentiation; cell cycle; apoptosis; monoblast}, language = {eng}, issn = {0301-4681}, journal = {Differentiation}, title = {p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts}, volume = {75}, year = {2007} }
TY - JOUR ID - 710231 AU - Navrátilová, Jarmila - Horváth, Viktor - Kozubík, Alois - Lojek, Antonín - Lipsick, Joseph - Šmarda, Jan PY - 2007 TI - p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts JF - Differentiation VL - 75 IS - 7 SP - 592-604 EP - 592-604 PB - Blackwell Publishing SN - 03014681 KW - p53 KW - differentiation KW - cell cycle KW - apoptosis KW - monoblast N2 - The p53 protein can control cell cycle progression, programmed cell death and differentiation of many cell types. In this work, we expressed human p53 protein in v-Myb-transformed chicken monoblasts. We found that even this protein possessing only 53% amino acid homology to its avian counterpart can significantly alter morphology and physiology of these cells causing the G2-phase cell cycle arrest and early monocytic differentiation. Our results document that the species-specific differences of the p53 molecules, promoters/enhancers, and co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilites of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein. The p53-induced differentiation and cell cycle arrest of v-Myb-transformed monoblasts are not associated with apoptosis suggesting that the p53-driven pathways controling apoptosis and differentiation/proliferation are independent. ER -
NAVRÁTILOVÁ, Jarmila, Viktor HORVÁTH, Alois KOZUBÍK, Antonín LOJEK, Joseph LIPSICK and Jan ŠMARDA. p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts. \textit{Differentiation}. Malden, USA: Blackwell Publishing, 2007, vol.~75, No~7, p.~592-604. ISSN~0301-4681.
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