| NAVRÁTILOVÁ, Jarmila, Viktor HORVÁTH, Alois KOZUBÍK, Antonín LOJEK, Joseph LIPSICK and Jan ŠMARDA. p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts. Differentiation. Malden, USA: Blackwell Publishing, 2007, vol. 75, No 7, p. 592-604. ISSN 0301-4681. |
Other formats:
BibTeX
LaTeX
RIS
@article{710231,
author = {Navrátilová, Jarmila and Horváth, Viktor and Kozubík, Alois and Lojek, Antonín and Lipsick, Joseph and Šmarda, Jan},
article_location = {Malden, USA},
article_number = {7},
keywords = {p53; differentiation; cell cycle; apoptosis; monoblast},
language = {eng},
issn = {0301-4681},
journal = {Differentiation},
title = {p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts},
volume = {75},
year = {2007}
}
TY - JOUR
ID - 710231
AU - Navrátilová, Jarmila - Horváth, Viktor - Kozubík, Alois - Lojek, Antonín - Lipsick, Joseph - Šmarda, Jan
PY - 2007
TI - p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts
JF - Differentiation
VL - 75
IS - 7
SP - 592-604
EP - 592-604
PB - Blackwell Publishing
SN - 03014681
KW - p53
KW - differentiation
KW - cell cycle
KW - apoptosis
KW - monoblast
N2 - The p53 protein can control cell cycle progression, programmed cell death and differentiation of many cell types. In this work, we expressed human p53 protein in v-Myb-transformed chicken monoblasts. We found that even this protein possessing only 53% amino acid homology to its avian counterpart can significantly alter morphology and physiology of these cells causing the G2-phase cell cycle arrest and early monocytic differentiation. Our results document that the species-specific differences of the p53 molecules, promoters/enhancers, and co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilites of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein. The p53-induced differentiation and cell cycle arrest of v-Myb-transformed monoblasts are not associated with apoptosis suggesting that the p53-driven pathways controling apoptosis and differentiation/proliferation are independent.
ER -
NAVRÁTILOVÁ, Jarmila, Viktor HORVÁTH, Alois KOZUBÍK, Antonín LOJEK, Joseph LIPSICK and Jan ŠMARDA. p53 arrests growth and induces differentiation of v-Myb-transformed monoblasts. \textit{Differentiation}. Malden, USA: Blackwell Publishing, 2007, vol.~75, No~7, p.~592-604. ISSN~0301-4681.
|
