Detailed Information on Publication Record
2006
Ultrashort Bradycardic Effect of Newly Synthetized Compounds
BARTOŠOVÁ, Ladislava, Marek FRYDRYCH, G. VACULOVÁ, K. BERÁNKOVÁ, Markéta BÉBAROVÁ et. al.Basic information
Original name
Ultrashort Bradycardic Effect of Newly Synthetized Compounds
Name in Czech
Ultrakrátký bradykardický efekt nově syntetizovaných látek
Authors
BARTOŠOVÁ, Ladislava (203 Czech Republic), Marek FRYDRYCH (203 Czech Republic), G. VACULOVÁ (203 Czech Republic), K. BERÁNKOVÁ (203 Czech Republic), Markéta BÉBAROVÁ (203 Czech Republic, guarantor), R. OPATŘILOVÁ (203 Czech Republic), V. STRNADOVÁ (203 Czech Republic), P. MOKRÝ (203 Czech Republic), V. BRUNCLÍK (203 Czech Republic), J. KOLEVSKÁ (203 Czech Republic), J. KRČMÁŘ (203 Czech Republic), L. BARTOŠÍKOVÁ (203 Czech Republic), T. FLORIAN (203 Czech Republic) and J. NEČAS (203 Czech Republic)
Edition
Acta Veterinaria Brunensis, Brno, 2006, 0001-7213
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30104 Pharmacology and pharmacy
Country of publisher
Czech Republic
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 0.491
RIV identification code
RIV/00216224:14110/06:00018544
Organization unit
Faculty of Medicine
UT WoS
000238911900005
Keywords in English
bradycardic effect;membrane currents;esmolol;rat;heart rate
Tags
International impact, Reviewed
Změněno: 12/6/2009 15:13, doc. MUDr. Markéta Bébarová, Ph.D.
V originále
Changes in heart rate induced by four different doses of two newly synthetized potential ultrashort-action antagonists of beta adrenergic receptors were tested in 90 male laboratory Wistar rats. Their effects were compared with esmolol. Both compounds demonstrated significant bradycardic effects and induced blockade of the fast sodium current (INa) and potassium currents (Ito, IK1, IK).
In Czech
Byly studovány změny tepové frekvence indukované čtyřmi dávkami dvou nově syntetizovaných potentciálních ultrakrátce působících beta blokátorů u 90 potkanů. Vliv byl srovnán s esmololem. Obě látky působily bradykardii a blokovaly sodíkový proud INa a draslíkové proudy Ito, IK1 a IK.
Links
| GA305/06/0863, research and development project |
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