BARTOŠOVÁ, Ladislava, Marek FRYDRYCH, G. VACULOVÁ, K. BERÁNKOVÁ, Markéta BÉBAROVÁ, R. OPATŘILOVÁ, V. STRNADOVÁ, P. MOKRÝ, V. BRUNCLÍK, J. KOLEVSKÁ, J. KRČMÁŘ, L. BARTOŠÍKOVÁ, T. FLORIAN and J. NEČAS. Ultrashort Bradycardic Effect of Newly Synthetized Compounds. Acta Veterinaria Brunensis. Brno, 2006, vol. 75, No 2, p. 183-196. ISSN 0001-7213.
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Basic information
Original name Ultrashort Bradycardic Effect of Newly Synthetized Compounds
Name in Czech Ultrakrátký bradykardický efekt nově syntetizovaných látek
Authors BARTOŠOVÁ, Ladislava (203 Czech Republic), Marek FRYDRYCH (203 Czech Republic), G. VACULOVÁ (203 Czech Republic), K. BERÁNKOVÁ (203 Czech Republic), Markéta BÉBAROVÁ (203 Czech Republic, guarantor), R. OPATŘILOVÁ (203 Czech Republic), V. STRNADOVÁ (203 Czech Republic), P. MOKRÝ (203 Czech Republic), V. BRUNCLÍK (203 Czech Republic), J. KOLEVSKÁ (203 Czech Republic), J. KRČMÁŘ (203 Czech Republic), L. BARTOŠÍKOVÁ (203 Czech Republic), T. FLORIAN (203 Czech Republic) and J. NEČAS (203 Czech Republic).
Edition Acta Veterinaria Brunensis, Brno, 2006, 0001-7213.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30104 Pharmacology and pharmacy
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 0.491
RIV identification code RIV/00216224:14110/06:00018544
Organization unit Faculty of Medicine
UT WoS 000238911900005
Keywords in English bradycardic effect;membrane currents;esmolol;rat;heart rate
Tags bradycardic effect, Esmolol, heart rate, membrane currents, rat
Tags International impact, Reviewed
Changed by Changed by: doc. MUDr. Markéta Bébarová, Ph.D., učo 15000. Changed: 12/6/2009 15:13.
Abstract
Changes in heart rate induced by four different doses of two newly synthetized potential ultrashort-action antagonists of beta adrenergic receptors were tested in 90 male laboratory Wistar rats. Their effects were compared with esmolol. Both compounds demonstrated significant bradycardic effects and induced blockade of the fast sodium current (INa) and potassium currents (Ito, IK1, IK).
Abstract (in Czech)
Byly studovány změny tepové frekvence indukované čtyřmi dávkami dvou nově syntetizovaných potentciálních ultrakrátce působících beta blokátorů u 90 potkanů. Vliv byl srovnán s esmololem. Obě látky působily bradykardii a blokovaly sodíkový proud INa a draslíkové proudy Ito, IK1 a IK.
Links
GA305/06/0863, research and development projectName: Stanovení základních farmakodynamických a farmakokinetických parametrů nově syntetizovaných látek ze skupiny ultrakrátce působících betalytik
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