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@article{712560,
author = {Hodek, P. and Hanuštiak, Pavel and Křížková, J. and Mikelová, Radka and Křížková, Soňa and Stiborová, M. and Trnková, Libuše and Horna, Aleš and Beklová, Miroslava and Kizek, René},
article_number = {suppl2},
keywords = {Flavonoids; interactions; biomacromolecules},
language = {eng},
issn = {0172-780X},
journal = {Neuroendocrinol. Lett.},
title = {Toxicological aspects of flavonoid interaction with biomacromolecules},
volume = {27},
year = {2006}
}
TY - JOUR
ID - 712560
AU - Hodek, P. - Hanuštiak, Pavel - Křížková, J. - Mikelová, Radka - Křížková, Soňa - Stiborová, M. - Trnková, Libuše - Horna, Aleš - Beklová, Miroslava - Kizek, René
PY - 2006
TI - Toxicological aspects of flavonoid interaction with biomacromolecules
JF - Neuroendocrinol. Lett.
VL - 27
IS - suppl2
SP - 14-17
EP - 14-17
SN - 0172780X
KW - Flavonoids
KW - interactions
KW - biomacromolecules
N2 - Flavonoids are widely accepted as health promoting phytochemicals, however, some flavonoids show ability of direct interaction with DNA and/or enhance carcinogen activation into DNA modifying agents. Thus, their potential harmful effect on the human body should be examined in detail. METHODS: Direct interaction of flavonoids (quercetin, rutin) with DNA was examined using square wave voltammetry on carbon paste electrode. Induction effect of selected flavonoids on content of cytochrome P450 1A1, carcinogens activating enzyme, in colon and liver microsomal samples of animals exposed to flavonoids was determined by Western blotting, using anti-cytochrome P450 1A1 specific antibody. RESULTS: Of the natural flavonoids tested, induction of CYP1A1 was elicited by the typical citrus flavonoid naringenin in the colon, as well as by flavone in the liver. Moreover, synthetic beta-naphthoflavone and naturally occurring chrysin, quercetin and diosmin induced CYP1A1 in both tissues. The oxidation signals of guanine and adenine in the DNA molecule were decreased in the presence of flavonoids.
ER -
HODEK, P., Pavel HANUŠTIAK, J. KŘÍŽKOVÁ, Radka MIKELOVÁ, Soňa KŘÍŽKOVÁ, M. STIBOROVÁ, Libuše TRNKOVÁ, Aleš HORNA, Miroslava BEKLOVÁ and René KIZEK. Toxicological aspects of flavonoid interaction with biomacromolecules. \textit{Neuroendocrinol. Lett.}. 2006, vol.~27, suppl2, p.~14-17. ISSN~0172-780X.
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