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@article{713129, author = {Juřica, Jan and Dostálek, Miroslav and Konečný, Jiří and Glatz, Zdeněk and Hadašová, Eva and Tomandl, Josef}, article_location = {Amsterdam, The Netherlands}, article_number = {1-2}, keywords = {cytochrome P450; midazolam; 1'-hydroxymidazolam; 4-hydroxymidazolam; 1'4-dihydroxymidazolam; rat; perfusion; plasma; HPLC}, language = {eng}, issn = {1570-0232}, journal = {Journal of Chromatography B}, note = {doi:10.1016/j.jchromb.2007.02.034}, title = {HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats}, url = {http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6X0P-4N4J320-4&_user=835458&_coverDate=06%2F01%2F2007&_alid=584152625&_rdoc=1&_fmt=summary&_orig=search&_cdi=7220&_sort=d&_st=4&_docanchor=&_ct=44&_acct=C000045159&_version=1&_urlVersion=0&_userid}, volume = {852}, year = {2007} }
TY - JOUR ID - 713129 AU - Juřica, Jan - Dostálek, Miroslav - Konečný, Jiří - Glatz, Zdeněk - Hadašová, Eva - Tomandl, Josef PY - 2007 TI - HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats JF - Journal of Chromatography B VL - 852 IS - 1-2 SP - 571-577 EP - 571-577 PB - Elsevier SN - 15700232 N1 - doi:10.1016/j.jchromb.2007.02.034 KW - cytochrome P450 KW - midazolam KW - 1'-hydroxymidazolam KW - 4-hydroxymidazolam KW - 1'4-dihydroxymidazolam KW - rat KW - perfusion KW - plasma KW - HPLC UR - http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6X0P-4N4J320-4&_user=835458&_coverDate=06%2F01%2F2007&_alid=584152625&_rdoc=1&_fmt=summary&_orig=search&_cdi=7220&_sort=d&_st=4&_docanchor=&_ct=44&_acct=C000045159&_version=1&_urlVersion=0&_userid N2 - A new, simple, rapid, sensitive, and repeatable isocratic reverse-phase HPLC method was developed and validated for simultaneous determination of midazolam and its main three hydroxylated metabolites, i.e. 1' hydroxymidazolam, 4-hydroxymidazolam, and 1',4-dihydroxymidazolam in rat liver perfusate and also plasma. Diazepam was used as an internal standard to ensure precision and accuracy of this method. This method is applicable for modeling and description of possible pharmacological interactions on rat (CYP3A1/2) or human (CYP3A4/5) cytochrome P450 enzymes. ER -
JUŘICA, Jan, Miroslav DOSTÁLEK, Jiří KONEČNÝ, Zdeněk GLATZ, Eva HADAŠOVÁ and Josef TOMANDL. HPLC determination of midazolam and its three hydroxy metabolites in perfusion medium and plasma from rats. \textit{Journal of Chromatography B}. Amsterdam, The Netherlands: Elsevier, 2007, vol.~852, 1-2, p.~571-577. ISSN~1570-0232.
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