Detailed Information on Publication Record
2006
GFP assay as a sensitive eukaryotic screening model to detect toxic and genotoxic activity of azaarenes.
BARTOŠ, Tomáš, Štefan LETZSCH, Michal ŠKAREK, Zuzana FLEGROVÁ, Pavel ČUPR et. al.Basic information
Original name
GFP assay as a sensitive eukaryotic screening model to detect toxic and genotoxic activity of azaarenes.
Name in Czech
Test GFP jako citlivý screeningový model k detekci toxicity a genotoxické aktivity azaarenů
Authors
BARTOŠ, Tomáš (203 Czech Republic), Štefan LETZSCH (276 Germany), Michal ŠKAREK (203 Czech Republic), Zuzana FLEGROVÁ (203 Czech Republic), Pavel ČUPR (203 Czech Republic, guarantor) and Ivan HOLOUBEK (203 Czech Republic)
Edition
Environmental Toxicology, USA, 2006, 1520-4081
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
30304 Public and environmental health
Country of publisher
United States of America
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 1.582
RIV identification code
RIV/00216224:14310/06:00018644
Organization unit
Faculty of Science
UT WoS
000239364500009
Keywords in English
azaarenes; GFP yeast bioassay; genotoxicity; toxicity
Tags
International impact, Reviewed
Změněno: 31/3/2010 22:49, doc. RNDr. Pavel Čupr, Ph.D.
V originále
Azaarenes are nitrogen-containing polyaromatic heterocyclic compounds (NPAHs). The majority of the azaarenes found in the environment originate from anthropogenic sources. Concentrations of NPAHs found in the environment are reported to be one to two orders of magnitude lower than polycyclic aromatic hydrocarbons (PAHs) concentrations, yet their biological effects can be of similar magnitude.Azaarenes are nitrogen-containing polyaromatic heterocyclic compounds (NPAHs). The majority of the azaarenes found in the environment originate from anthropogenic sources. Concentrations of NPAHs found in the environment are reported to be one to two orders of magnitude lower than polycyclic aromatic hydrocarbons (PAHs) concentrations, yet their biological effects can be of similar magnitude. To assess the toxic and genotoxic activity, a green fluorescent protein (GFP) assay based on the yeast Saccharomyces cerevisiae was selected. In this study, the authors present evidence that genotoxicity assessment using the yeast GFP assay can provide a simple system to monitor the activity of these environmental pollutants that could possess mutagenic potential at low concentrations.
In Czech
Test GFP jako citlivý screeningový model k detekci toxicity a genotoxické aktivity azaarenů
Links
| MSM0021622412, plan (intention) |
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