Detailed Information on Publication Record
2006
The functional role of cardiac T-tubules in a model of rat ventricular myocytes
PÁSEK, Michal, Jiří ŠIMURDA and Georges CHRISTÉBasic information
Original name
The functional role of cardiac T-tubules in a model of rat ventricular myocytes
Name in Czech
Funkční role srdečních T-tubulů v modelu komorové buňky krysy
Authors
PÁSEK, Michal (203 Czech Republic, guarantor), Jiří ŠIMURDA (203 Czech Republic) and Georges CHRISTÉ (250 France)
Edition
Philosophical Transactions of the Royal Society, London (UK), The Royal Society, 2006, 1364-503X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10610 Biophysics
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 2.282
RIV identification code
RIV/00216224:14110/06:00015542
Organization unit
Faculty of Medicine
UT WoS
000237189500006
Keywords in English
accumulation-depletion of ions; transverse tubule; heart; mathematical model; cardiomyocyte; rat
Tags
Tags
International impact, Reviewed
Změněno: 25/6/2009 16:01, doc. Ing. Michal Pásek, Ph.D.
V originále
The morphology of the cardiac transverse axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. In the model, the action potentials initiated in current clamp mode were accompanied by transient K+ accumulation and transient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady state stimulation frequencies of 1 to 5 Hz. Ca2+ depletion increased from 7 % to 13.1 % with stimulation frequency, while K+ accumulation decreased from 4.1 % to 2.7 %. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart.
In Czech
Práce popisuje výsledky vyšetření fyziologických důsledků iontově koncentračních změn v transverzálně-axiálním tubulárním systému u srdeční komorové buňky potkana. Vyšetření je provedeno na představeném matematickém modelu.
Links
| AV0Z20760514, plan (intention) |
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| MSM0021622402, plan (intention) |
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