| PÁSEK, Michal, Jiří ŠIMURDA and Georges CHRISTÉ. The functional role of cardiac T-tubules in a model of rat ventricular myocytes. Philosophical Transactions of the Royal Society. London (UK): The Royal Society, 2006, vol. 364, No 1842, p. 1187-1206. ISSN 1364-503X. |
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@article{717063,
author = {Pásek, Michal and Šimurda, Jiří and Christé, Georges},
article_location = {London (UK)},
article_number = {1842},
keywords = {accumulation-depletion of ions; transverse tubule; heart; mathematical model; cardiomyocyte; rat},
language = {eng},
issn = {1364-503X},
journal = {Philosophical Transactions of the Royal Society},
title = {The functional role of cardiac T-tubules in a model of rat ventricular myocytes},
volume = {364},
year = {2006}
}
TY - JOUR
ID - 717063
AU - Pásek, Michal - Šimurda, Jiří - Christé, Georges
PY - 2006
TI - The functional role of cardiac T-tubules in a model of rat ventricular myocytes
JF - Philosophical Transactions of the Royal Society
VL - 364
IS - 1842
SP - 1187-1206
EP - 1187-1206
PB - The Royal Society
SN - 1364503X
KW - accumulation-depletion of ions
KW - transverse tubule
KW - heart
KW - mathematical model
KW - cardiomyocyte
KW - rat
N2 - The morphology of the cardiac transverse axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. In the model, the action potentials initiated in current clamp mode were accompanied by transient K+ accumulation and transient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady state stimulation frequencies of 1 to 5 Hz. Ca2+ depletion increased from 7 % to 13.1 % with stimulation frequency, while K+ accumulation decreased from 4.1 % to 2.7 %. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart.
ER -
PÁSEK, Michal, Jiří ŠIMURDA and Georges CHRISTÉ. The functional role of cardiac T-tubules in a model of rat ventricular myocytes. \textit{Philosophical Transactions of the Royal Society}. London (UK): The Royal Society, 2006, vol.~364, No~1842, p.~1187-1206. ISSN~1364-503X.
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