J 2006

The functional role of cardiac T-tubules in a model of rat ventricular myocytes

PÁSEK, Michal, Jiří ŠIMURDA and Georges CHRISTÉ

Basic information

Original name

The functional role of cardiac T-tubules in a model of rat ventricular myocytes

Name in Czech

Funkční role srdečních T-tubulů v modelu komorové buňky krysy

Authors

PÁSEK, Michal (203 Czech Republic, guarantor), Jiří ŠIMURDA (203 Czech Republic) and Georges CHRISTÉ (250 France)

Edition

Philosophical Transactions of the Royal Society, London (UK), The Royal Society, 2006, 1364-503X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10610 Biophysics

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.282

RIV identification code

RIV/00216224:14110/06:00015542

Organization unit

Faculty of Medicine

UT WoS

000237189500006

Keywords in English

accumulation-depletion of ions; transverse tubule; heart; mathematical model; cardiomyocyte; rat

Tags

Tags

International impact, Reviewed
Změněno: 25/6/2009 16:01, doc. Ing. Michal Pásek, Ph.D.

Abstract

ORIG CZ

V originále

The morphology of the cardiac transverse axial tubular system (TATS) has been known for decades, but its function has received little attention. To explore the possible role of this system in the physiological modulation of electrical and contractile activity, we have developed a mathematical model of rat ventricular cardiomyocytes in which the TATS is described as a single compartment. In the model, the action potentials initiated in current clamp mode were accompanied by transient K+ accumulation and transient Ca2+ depletion in the TATS lumen. The amplitude of these changes relative to external ion concentrations was studied at steady state stimulation frequencies of 1 to 5 Hz. Ca2+ depletion increased from 7 % to 13.1 % with stimulation frequency, while K+ accumulation decreased from 4.1 % to 2.7 %. These ionic changes (particularly Ca2+ depletion) implicated significant decrease of intracellular Ca2+ load at frequencies natural for rat heart.

In Czech

Práce popisuje výsledky vyšetření fyziologických důsledků iontově koncentračních změn v transverzálně-axiálním tubulárním systému u srdeční komorové buňky potkana. Vyšetření je provedeno na představeném matematickém modelu.

Links

AV0Z20760514, plan (intention)
Name: Komplexní dynamické systémy v termodynamice, mechanice tekutin a těles
MSM0021622402, plan (intention)
Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases