PÁSEK, Michal, Jiří ŠIMURDA, Clive ORCHARD and Georges CHRISTÉ. Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study. In Main Meeting of the Physiological Society (London). 2006.
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Basic information
Original name Activity-dependent changes of [Ca2+] in the transverse-axial tubular system reduce SR Ca2+ content and Ca2+ transient amplitude in rat and guinea pig cardiac ventricular myocytes: a simulation study
Name in Czech Aktivitou-podmíněné změny [Ca2+] v transverzálně-axiálním tubulárním systému redukují obsah Ca2+ v SR a snižují amplitudu přechodných změn Ca2+ v cytoplazmě v modelu komorové srdeční buňky potkana a morčete
Authors PÁSEK, Michal (203 Czech Republic, guarantor), Jiří ŠIMURDA (203 Czech Republic), Clive ORCHARD (826 United Kingdom of Great Britain and Northern Ireland) and Georges CHRISTÉ (250 France).
Edition Main Meeting of the Physiological Society (London), 2006.
Other information
Original language English
Type of outcome Conference abstract
Field of Study 10610 Biophysics
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
RIV identification code RIV/00216224:14110/06:00015543
Organization unit Faculty of Medicine
Keywords in English cardiac cell; T-tubule; quantitative modelling
Tags Cardiac cell, Quantitative modelling, T-tubule
Tags International impact, Reviewed
Changed by Changed by: doc. Ing. Michal Pásek, Ph.D., učo 46541. Changed: 3/1/2010 18:00.
Abstract
To explore the physiological consequences of ion concentration changes in the transverse-axial tubular system (TATS) of rat and guinea-pig cardiac ventricular myocytes, we have developed mathematical models of their electrical activity that include a quantitative description of the TATS. In both models, transient depletion of tubular Ca2+ occurred during each action potential and decreased intracellular Ca2+ load and consequently systolic Ca2+ transient amplitude. However, the magnitude of this effect and its frequency dependence was different in the two species.
Abstract (in Czech)
Práce popisuje výsledky vyšetření fyziologických důsledků iontově koncentračních změn v transverzálně–axiálním tubulárním systému u komorových srdečních buněk potkana a morčete. Vyšetření je provedeno na matematických modelech.
Links
AV0Z20760514, plan (intention)Name: Komplexní dynamické systémy v termodynamice, mechanice tekutin a těles
MSM0021622402, plan (intention)Name: Časná diagnostika a léčba kardiovaskulárních chorob
Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases
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