Elastic properties of ribosomal RNA building blocks: Molecular dynamics study

RÁZGA, Filip, Jaroslav KOČA and Jiří ŠPONER. Elastic properties of ribosomal RNA building blocks: Molecular dynamics study. In Strukturní biofyzika makromolekul II. první. Brno: Brno, 2007, p. 14-14.

Basic information

Original name

Elastic properties of ribosomal RNA building blocks: Molecular dynamics study

Name in Czech

Elastické vlastnosti stavebných blokov ribozomálnej RNA: Molekulovo dynamická štúdia

Authors

RÁZGA, Filip, Jaroslav KOČA and Jiří ŠPONER

Edition

první. Brno, Strukturní biofyzika makromolekul II, p. 14-14, 1 pp. 2007

Publisher

Brno

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Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

10403 Physical chemistry

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Science

Keywords in English

RNA flexibility; Molecular dynamics

Tags

molecular dynamics, RNA flexibility

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Abstract

V originále

Explicit solvent Molecular Dynamics was used to describe the intrinsic flexibility of 23S rRNA Kink-turn motifs (e.g. Kt-38, Kt-42, Kt-58) and 23S rRNA Helix 42-44 (i.e. GTPase associated center rRNA with adjacent Kt-42). We demonstrate how rRNA building blocks with contrasting intrinsic flexibilities can form larger architectures with highly specific patterns of preferred low-energy motions and geometries. Additionally, the preferred low-energy motions of different rRNA motifs (e.g. 23S rRNA Kink-turn motifs, 23S rRNA Helix 42-44 (i.e. GTPase associated center rRNA), 23S rRNA Helix 90-92 (i.e. three-way-junction with A-loop), 23S Sarcin-ricin loop, 16S rRNA Helix 44 and 5S rRNA loop E) will be compared and discussed.

In Czech

Explicit solvent Molecular Dynamics was used to describe the intrinsic flexibility of 23S rRNA Kink-turn motifs (e.g. Kt-38, Kt-42, Kt-58) and 23S rRNA Helix 42-44 (i.e. GTPase associated center rRNA with adjacent Kt-42). We demonstrate how rRNA building blocks with contrasting intrinsic flexibilities can form larger architectures with highly specific patterns of preferred low-energy motions and geometries. Additionally, the preferred low-energy motions of different rRNA motifs (e.g. 23S rRNA Kink-turn motifs, 23S rRNA Helix 42-44 (i.e. GTPase associated center rRNA), 23S rRNA Helix 90-92 (i.e. three-way-junction with A-loop), 23S Sarcin-ricin loop, 16S rRNA Helix 44 and 5S rRNA loop E) will be compared and discussed.