Two common polymorphisms in leptin and adiponectin genes are
not associated with preeclampsia in the Czech population

a 2007

Two common polymorphisms in leptin and adiponectin genes are not associated with preeclampsia in the Czech population

BIENERTOVÁ VAŠKŮ, Julie, Kateřina KAŇKOVÁ, Zuzana DOSTÁLOVÁ, Petr BIENERT, Anna VAŠKŮ et. al.

Basic information

Original name

Two common polymorphisms in leptin and adiponectin genes are not associated with preeclampsia in the Czech population

Name in Czech

Dva v populaci četné polymorfismy v genech pro leptin a adiponektin nejsou asociovány s preeklampsií u českých žen

Authors

BIENERTOVÁ VAŠKŮ, Julie, Kateřina KAŇKOVÁ, Zuzana DOSTÁLOVÁ, Petr BIENERT and Anna VAŠKŮ

Edition

International Journal of Obesity, vol 37, no 1, 2007

Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30202 Endocrinology and metabolism

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 3.560

Organization unit

Faculty of Medicine

ISSN

UT WoS

000245832700520

Keywords in English

leptin; adiponektin; preeclampsia; gene

Abstract

ORIG CZ

V originále

Introduction Leptin and adiponectin are both adipocyte-derived hormones that regulate food intake and have also autocrine-paracrine effects. Leptin has been previously reported to control the integrity of fetoplacental unit by virtue of its immunomodulatory property mediated via T-lymphocytes. Dysregulation of complex interactions of various adipokines is supposed to be implicated in the pathogenesis of recurrent miscarriage, gestational diabetes or preeclampsia. In this study, we investigated whether two common polymorphisms in leptin and adiponectin gene were associated with preeclampsia and its related variables (blood pressure, proteinuria, glucose concentrations, and anthropometric parameters of the newborns). Methods A total of 140 preeclamptic women and 153 healthy controls were genotyped for the T94G in the adiponectin (APM1) gene exon 2 and the G-2548A in the leptin (LEP) gene promoter. Results The allelic frequency of G allele of LEP G-2548A was 0.541 in preeclamptic women vs. 0.583 in age-matched healthy pregnant controls (pa=0.316); the frequency of G allele of APM1 T94G was 0.073 in preeclamptic cases and 0.079 in healthy controls (pa=0.762), respectively. No significant associations were detected between the two SNPs evaluated and the anthropometric variables including BMI, blood pressure, glucose, fibrinogene concentrations and the birth length and weight of the newborns from these pathological vs. physiological pregnancies. Conclusion To conclude, the APM1 T94G and LEP G-2548A polymorphisms do not seem to be major genetic determinants of preeclampsia in Czech Caucasian population.

In Czech

Na základě našich výsledků nelze polymorfismy APM1 T94G a LEP G-2548A považovat za významné genetické determinanty preeclampsie v české populaci.

Citovat

BIENERTOVÁ VAŠKŮ, Julie, Kateřina KAŇKOVÁ, Zuzana DOSTÁLOVÁ, Petr BIENERT and Anna VAŠKŮ. Two common polymorphisms in leptin and adiponectin genes are not associated with preeclampsia in the Czech population. In International Journal of Obesity, vol 37, no 1. 2007. ISSN 0307-0565.

@proceedings{717852,
   author = {Bienertová Vašků, Julie and Kaňková, Kateřina and Dostálová, Zuzana and Bienert, Petr and Vašků, Anna},
   booktitle = {International Journal of Obesity, vol 37, no 1},
   keywords = {leptin; adiponektin; preeclampsia; gene},
   language = {eng},
   title = {Two common polymorphisms in leptin and adiponectin genes are not associated with preeclampsia in the Czech population},
   year = {2007}
}

TY  - CONF
ID  - 717852
AU  - Bienertová Vašků, Julie - Kaňková, Kateřina - Dostálová, Zuzana - Bienert, Petr - Vašků, Anna
PY  - 2007
TI  - Two common polymorphisms in leptin and adiponectin genes are not associated with preeclampsia in the Czech population
KW  - leptin
KW  - adiponektin
KW  - preeclampsia
KW  - gene
N2  - Introduction Leptin and adiponectin are both adipocyte-derived hormones that regulate food intake and have also autocrine-paracrine effects. Leptin has been previously reported to control the integrity of fetoplacental unit by virtue of its immunomodulatory property mediated via T-lymphocytes. Dysregulation of complex interactions of various adipokines is supposed to be implicated in the pathogenesis of recurrent miscarriage, gestational diabetes or preeclampsia. In this study, we investigated whether two common polymorphisms in leptin and adiponectin gene were associated with preeclampsia and its related variables (blood pressure, proteinuria, glucose concentrations, and anthropometric parameters of the newborns). Methods A total of 140 preeclamptic women and 153 healthy controls were genotyped for the T94G in the adiponectin (APM1) gene exon 2 and the G-2548A in the leptin (LEP) gene promoter. Results The allelic frequency of G allele of LEP G-2548A was 0.541 in preeclamptic women vs. 0.583 in age-matched healthy pregnant controls (pa=0.316); the frequency of G allele of APM1 T94G was 0.073 in preeclamptic cases and 0.079 in healthy controls (pa=0.762), respectively. No significant associations were detected between the two SNPs evaluated and the anthropometric variables including BMI, blood pressure, glucose, fibrinogene concentrations and the birth length and weight of the newborns from these pathological vs. physiological pregnancies. Conclusion To conclude, the APM1 T94G and LEP G-2548A polymorphisms do not seem to be major genetic determinants of preeclampsia in Czech Caucasian population.
ER  -

BIENERTOVÁ VAŠKŮ, Julie, Kateřina KAŇKOVÁ, Zuzana DOSTÁLOVÁ, Petr BIENERT and Anna VAŠKŮ. Two common polymorphisms in leptin and adiponectin genes are not associated with preeclampsia in the Czech population. In \textit{International Journal of Obesity, vol 37, no 1}. 2007. ISSN~0307-0565.

Detailed Information on Publication Record