PALČÍKOVÁ, Ivana, Alexandra ŽOURKOVÁ, Daria VALENTOVÁ and Eva HADAŠOVÁ. Mental bulimia , paroxetine treatment and phenotype monitoring of CYP2D6 activity. In Addiction and Eating Disorders, Neurobiology nad Comorbidities, Workshop. Brno: Masaryk University Conference Centre, Czech Republic, Brno, 2007, p. 59-60. ISBN 978-80-87041-18-5.
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Basic information
Original name Mental bulimia , paroxetine treatment and phenotype monitoring of CYP2D6 activity
Name in Czech Sledování fenotypových změn CYP2D6 při léčbě bulimie paroxetinem
Authors PALČÍKOVÁ, Ivana, Alexandra ŽOURKOVÁ, Daria VALENTOVÁ and Eva HADAŠOVÁ.
Edition Brno, Addiction and Eating Disorders, Neurobiology nad Comorbidities, Workshop, p. 59-60, 2 pp. 2007.
Publisher Masaryk University Conference Centre, Czech Republic, Brno
Other information
Original language English
Type of outcome Proceedings paper
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Organization unit Faculty of Medicine
ISBN 978-80-87041-18-5
Keywords in English bulimia; CYP2D6; paroxetine
Tags bulimia, CYP2D6, paroxetine
Changed by Changed by: MUDr. Ivana Palčíková, učo 22333. Changed: 20/5/2007 15:50.
Abstract
P450 enzymes are oxidase systems. These enzymes oxidize endogenous and exogenous compounds and usually render them less active, preparing them for elimination from the body. More than 40 individual P450 enzymes have been identified. 2D6 play important role in drug metabolism. SSRI (serotonin reuptake inhibitors) therapy is used in bulimia. There are SSRI, especially paroxetine, with a SSRI-inhibiting effect. This fact may lead to a change of phenotype. Phenotyping enables to identify the current activity of the enzyme. The study included patients diagnosed with bulimia. The goal of the study was to evaluate the efficacy of paroxetine treatment in female patients with mental bulimia (MB) while monitoring CYP2D6 activity. Treatment was evaluated on EAT, HAMA, CGI and UKU scales. CYP2D6 activity phenotyping was performed using the dextromethorphan test. The expectation of a significant improvement in poor metabolizers and consequently slower paroxetine degradation was confirmed on the scale for eating behaviour.
Abstract (in Czech)
Léčba pacientek s mentální bulimií byla hodnocena prostřednictvím škál EAT, HAMA, CGI a UKU. Fenotypizace probíhala prostřednictvím dextrometorfanového testu. Očekávané zlepšení u bulimických pacientek s pomalou metabolizací se potvrdilo na škále EAT.
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
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