p53 arrests growth and induces differentiation of v-myb-transformed monoblasts

ŠMARDA, Jan, Jarmila NAVRÁTILOVÁ, Viktor HORVÁTH, Alois KOZUBÍK and Antonín LOJEK. p53 arrests growth and induces differentiation of v-myb-transformed monoblasts. In Molecular Aspects of myeloid stem cell development and leukemia. Annapolis, USA: Leukemia and Lymphoma Society, 2007, p. 64-64.

Basic information

Original name

p53 arrests growth and induces differentiation of v-myb-transformed monoblasts

Name in Czech

protein p53 zastavuje růst a indukuje diferenciaci monoblastů transformovaných onkogenem v-myb

Authors

ŠMARDA, Jan (203 Czech Republic, guarantor), Jarmila NAVRÁTILOVÁ (203 Czech Republic), Viktor HORVÁTH (203 Czech Republic), Alois KOZUBÍK (203 Czech Republic) and Antonín LOJEK (203 Czech Republic)

Edition

Annapolis, USA, Molecular Aspects of myeloid stem cell development and leukemia, p. 64-64, 1 pp. 2007

Publisher

Leukemia and Lymphoma Society

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Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/07:00020250

Organization unit

Faculty of Science

UT WoS

000248966900003

Keywords in English

Myb; p53; differentiation; apoptosis; cell growth

Tags

apoptosis, cell growth, differentiation, Myb, p53

Tags

International impact, Reviewed

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Abstract

V originále

Ectopic expression of human p53 in avian leukemic monoblasts BM2 induces cell cycle arrest in G2, early monocytic differentiation but no apoptosis. This suggests that the species-specific differences of the p53 molelecules,promoter/enhancers, co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilities of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein.

In Czech

Ektopická exprese lidského proteinu p53 v ptačích leukemických monoblastech zastavuje buněčný cyklus ve fázi G2 a indukuje ranou monocytickou diferenciaci, ale ne apoptózu. Tento výsledek naznačuje, že mezidruhové rozdíly mezi molekulami p53, promoter/enhancery a kofaktory v ptačích a lidských buňkách nenarušují schopnost nádorového supresoru p53 stimulovat diferenciaci a blokovat proliferaci a to dokonce za přítomnosti funkčního onkoproteinu v-Myb.

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Links

GA301/06/0036, research and development project	Name: Úloha vybraných transkripčních faktorů v osteoklastové diferenciační dráze Investor: Czech Science Foundation, A role of certain transcription factors in the osteoclastic differentiation pathway
MSM0021622415, plan (intention)	Name: Molekulární podstata buněčných a tkáňových regulací Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations