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@inproceedings{718340,
author = {Šmarda, Jan and Navrátilová, Jarmila and Horváth, Viktor and Kozubík, Alois and Lojek, Antonín},
address = {Annapolis, USA},
booktitle = {Molecular Aspects of myeloid stem cell development and leukemia},
keywords = {Myb; p53; differentiation; apoptosis; cell growth},
language = {eng},
location = {Annapolis, USA},
pages = {64-64},
publisher = {Leukemia and Lymphoma Society},
title = {p53 arrests growth and induces differentiation of v-myb-transformed monoblasts},
year = {2007}
}
TY - JOUR
ID - 718340
AU - Šmarda, Jan - Navrátilová, Jarmila - Horváth, Viktor - Kozubík, Alois - Lojek, Antonín
PY - 2007
TI - p53 arrests growth and induces differentiation of v-myb-transformed monoblasts
PB - Leukemia and Lymphoma Society
CY - Annapolis, USA
KW - Myb
KW - p53
KW - differentiation
KW - apoptosis
KW - cell growth
N2 - Ectopic expression of human p53 in avian leukemic monoblasts BM2 induces cell cycle arrest in G2, early monocytic differentiation but no apoptosis. This suggests that the species-specific differences of the p53 molelecules,promoter/enhancers, co-factors in avian and human cells do not interfere with differentiation- and cell cycle arrest promoting capabilities of the p53 tumor suppressor even in the presence of functional v-Myb oncoprotein.
ER -
ŠMARDA, Jan, Jarmila NAVRÁTILOVÁ, Viktor HORVÁTH, Alois KOZUBÍK and Antonín LOJEK. p53 arrests growth and induces differentiation of v-myb-transformed monoblasts. In \textit{Molecular Aspects of myeloid stem cell development and leukemia}. Annapolis, USA: Leukemia and Lymphoma Society, 2007, p.~64-64.
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