Influence of age, body mass index, and blood pressure on the
carotic intima-media thickness in normotensives and
hypertensives.

D 2006

Influence of age, body mass index, and blood pressure on the carotic intima-media thickness in normotensives and hypertensives.

HONZÍKOVÁ, Nataša, Růžena LÁBROVÁ, Bohumil FIŠER, Eva MADĚROVÁ, Z NOVÁKOVÁ et. al.

Basic information

Original name

Influence of age, body mass index, and blood pressure on the carotic intima-media thickness in normotensives and hypertensives.

Name in Czech

Vliv věku, BMI a krevního tlaku na tloušťku intimy medie karotické tepny u normotenzních a hypertenzních osob

Authors

HONZÍKOVÁ, Nataša, Růžena LÁBROVÁ, Bohumil FIŠER, Eva MADĚROVÁ, Z NOVÁKOVÁ, Eva ZÁVODNÁ and Bořivoj SEMRÁD

Edition

2006

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

30105 Physiology

Country of publisher

Germany

Confidentiality degree

není předmětem státního či obchodního tajemství

Organization unit

Faculty of Medicine

Keywords (in Czech)

věk; body mass index; krevní tlak; tloušťka intimy medie karotických tepen; hypertenze

Keywords in English

age; body mass index; blood pressure; carotic intima-media thickness; hypertension.

Abstract

ORIG CZ

V originále

We investigated whether body mass index and blood pressure have an additive influence on the carotid intima-media thickness (IMT). In 27 patients treated for hypertension (47.2 +/- 8.7 years) and 23 normotensive subjects (44.1 +/- 8.1 years), 24-h recording of blood pressure was performed. The carotid IMT was determined by ultrasonography and baroreflex sensitivity by a spectral method from 5-min recordings of blood pressure. Significant differences between hypertensive and normotensive subjects were observed for carotid IMT (0.60 +/- 0.08 vs. 0.51 +/- 0.07 mm; p < 0.001) and baroreflex sensitivity (3.5 +/- 1.8 vs. 5.6 +/- 2.1 ms/mm Hg; p < 0.001). Hierarchical multiple regression analysis (p < 0.01) showed that carotid IMT was positively correlated with age (p < 0.001) and body mass index (p < 0.05) in normotensive subjects. The increased carotid IMT in hypertensive patients was not additively influenced by either age or body mass index. Baroreflex sensitivity decreased with age (p<0.01) and with carotid IMT (p<0.05) in normotensive subjects only. Multiregression analysis showed that an additive influence of age and body mass index on the development of carotid IMT is essential only in normotensive subjects. In hypertensive subjects the influence of blood pressure predominates, as documented by a comparison of the carotid IMT between hypertensive and normotensive subjects.

In Czech

Cílem práce bylo zjistit, zda body mass index a krevní tlak mají vliv na tloušťku intimy medie karotických tepen.

Links

MSM0021622402, plan (intention)

Name: Časná diagnostika a léčba kardiovaskulárních chorob

Investor: Ministry of Education, Youth and Sports of the CR, Early diagnostics and treatment of cardiovascular diseases

Citovat

HONZÍKOVÁ, Nataša, Růžena LÁBROVÁ, Bohumil FIŠER, Eva MADĚROVÁ, Z NOVÁKOVÁ, Eva ZÁVODNÁ and Bořivoj SEMRÁD. Influence of age, body mass index, and blood pressure on the carotic intima-media thickness in normotensives and hypertensives. 2006.

@inproceedings{718446,
   author = {Honzíková, Nataša and Lábrová, Růžena and Fišer, Bohumil and Maděrová, Eva and Nováková, Z and Závodná, Eva and Semrád, Bořivoj},
   keywords = {age; body mass index; blood pressure; carotic intima-media thickness; hypertension.},
   language = {eng},
   title = {Influence of age, body mass index, and blood pressure on the carotic intima-media thickness in normotensives and hypertensives.},
   year = {2006}
}

TY  - JOUR
ID  - 718446
AU  - Honzíková, Nataša - Lábrová, Růžena - Fišer, Bohumil - Maděrová, Eva - Nováková, Z - Závodná, Eva - Semrád, Bořivoj
PY  - 2006
TI  - Influence of age, body mass index, and blood pressure on the carotic intima-media thickness in normotensives and hypertensives.
KW  - age
KW  - body mass index
KW  - blood pressure
KW  - carotic intima-media thickness
KW  - hypertension.
N2  - We investigated whether body mass index and blood pressure have an additive influence on the carotid intima-media thickness (IMT). In 27 patients treated for hypertension (47.2 +/- 8.7 years) and 23 normotensive subjects (44.1 +/- 8.1 years), 24-h recording of blood pressure was performed. The carotid IMT was determined by ultrasonography and baroreflex sensitivity by a spectral method from 5-min recordings of blood pressure. Significant differences between hypertensive and normotensive subjects were observed for carotid IMT (0.60 +/- 0.08 vs. 0.51 +/- 0.07 mm; p < 0.001) and baroreflex sensitivity (3.5 +/- 1.8 vs. 5.6 +/- 2.1 ms/mm Hg; p < 0.001). Hierarchical multiple regression analysis (p < 0.01) showed that carotid IMT was positively correlated with age (p < 0.001) and body mass index (p < 0.05) in normotensive subjects. The increased carotid IMT in hypertensive patients was not additively influenced by either age or body mass index. Baroreflex sensitivity decreased with age (p<0.01) and with carotid IMT (p<0.05) in normotensive subjects only. Multiregression analysis showed that an additive influence of age and body mass index on the development of carotid IMT is essential only in normotensive subjects. In hypertensive subjects the influence of blood pressure predominates, as documented by a comparison of the carotid IMT between hypertensive and normotensive subjects.
ER  -

HONZÍKOVÁ, Nataša, Růžena LÁBROVÁ, Bohumil FIŠER, Eva MADĚROVÁ, Z NOVÁKOVÁ, Eva ZÁVODNÁ and Bořivoj SEMRÁD. \textit{Influence of age, body mass index, and blood pressure on the carotic intima-media thickness in normotensives and hypertensives.}. 2006.

Detailed Information on Publication Record