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@article{718661, author = {Bienertová Vašků, Julie and Hlinomaz, Ota and Vašků, Anna}, article_location = {Japan}, article_number = {22(5)}, keywords = {leptin; restenosis; gene; polymorphism}, language = {eng}, issn = {0910-8327}, journal = {Heart Vessels}, title = {Are common leptin promoter polymorphisms associated with restenosis after coronary stenting?}, volume = {2007}, year = {2007} }
TY - JOUR ID - 718661 AU - Bienertová Vašků, Julie - Hlinomaz, Ota - Vašků, Anna PY - 2007 TI - Are common leptin promoter polymorphisms associated with restenosis after coronary stenting? JF - Heart Vessels VL - 2007 IS - 22(5) SP - 310-5 EP - 310-5 PB - Springer Japan SN - 09108327 KW - leptin KW - restenosis KW - gene KW - polymorphism N2 - The hypertrophy of vascular smooth muscle cells as well as neointimal proliferation is critical in vascular remodeling, whereas leptin has proved to play an important role recently. The aim of the study was to investigate possible associations of two common leptin gene polymorphisms with restenosis after percutaneous coronary intervention (PCI). To study the association of two promoter polymorphisms, LEP 2548 G/A and LEP 188 C/A (dbSNP ID rs7799039 and rs791620) with neointimal proliferation in humans, 98 consecutive patients undergoing stenting into small coronary arteries (<3 mm) were genotyped. After a 6 month follow up, the restenosis rate was estimated. Restenosis >50% occurred in 33.3% of patients carrying both A alleles, 33.3% of carriers of A and C alleles, and 31.4% of carriers of two CC alleles of LEP 188 C/A polymorphism; and in 25.0% of patients with AA, 32.7% with AG, and 30.4% with GG genotype of LEP 2548 G/A polymorphism. Interestingly, the heterozygote AG genotype of LEP 2548 polymorphism represented a highly signifi cant risk for multiple vessel disease when compared to both homozygote genotypes AA/GG (odds ratio = 4.038, 95% confidence interval: 1.732 to 9.465, Pcorr = 0.001). Based on our findings, the AG genotype of LEP 2548 G/A polymorphism might be considered a genetic marker for multiple vessel disease but not for restenosis after PCI. The role of the leptin gene polymorphisms as genetic markers of restenosis will require further investigation to elucidate the underlying pathophysiological consequences. ER -
BIENERTOVÁ VAŠKŮ, Julie, Ota HLINOMAZ and Anna VAŠKŮ. Are common leptin promoter polymorphisms associated with restenosis after coronary stenting? \textit{Heart Vessels}. Japan: Springer Japan, 2007, vol.~2007, 22(5), p.~310-5, 6 pp. ISSN~0910-8327.
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