D 2007

Genomic PCR simulation with hardware-accelerated approximate sequence matching

LEXA, Matej, Tomáš MARTÍNEK, Patrik BECK, Otto FUČÍK, Giorgio VALLE et. al.

Basic information

Original name

Genomic PCR simulation with hardware-accelerated approximate sequence matching

Name in Czech

Simulace genomové PCR s hardwarově urychlovaným přibližným vyhledáváním sekvencí

Authors

LEXA, Matej (703 Slovakia, guarantor, belonging to the institution), Tomáš MARTÍNEK (203 Czech Republic), Patrik BECK (703 Slovakia), Otto FUČÍK (203 Czech Republic), Giorgio VALLE (380 Italy) and Ivano ZARA (380 Italy)

Edition

Praha, Proceedings 21st European Conference on Modelling and Simulation, p. 333-338, 6 pp. 2007

Publisher

ECMS

Other information

Language

English

Type of outcome

Stať ve sborníku

Field of Study

20206 Computer hardware and architecture

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14330/07:00041408

Organization unit

Faculty of Informatics

ISBN

978-0-9553018-2-7

UT WoS

000252306400053

Keywords in English

Virtual PCR; FPGA; sequence alignment; mathematical model

Tags

International impact, Reviewed
Změněno: 27/4/2011 09:54, doc. Ing. Matej Lexa, Ph.D.

Abstract

V originále

We report the latest details on improvements made or planned for the VPCR simulation software currently accessible on the Internet. We describe the inner workings of the dynamic amplification simulation model, concentrating mostly on the time- and sensitivity-critical step of sequence matching. Replacement of BLAST by the more sensitive and faster PRMEX similarity search program resulted in a marked improvement of PCR product predictions. Further speed improvements were acheived using hardware acceleration of approximate sequence matching.

In Czech

Publikace popisuje vylepšení programu pro simulaci PCR na genomových templátech s využitím programu PRIMEX a programovatelného hardwaru na báze FPGA čipů.

Links

MSM0021622419, plan (intention)
Name: Vysoce paralelní a distribuované výpočetní systémy
Investor: Ministry of Education, Youth and Sports of the CR, Highly Parallel and Distributed Computing Systems