J 2007

C-Geranyl Compounds from <i>Paulownia tomentosa</i> Fruits

ŠMEJKAL, Karel, Lenka GRYCOVÁ, Radek MAREK, Filip LEMIERE, Dagmar JANKOVSKÁ et. al.

Basic information

Original name

C-Geranyl Compounds from <i>Paulownia tomentosa</i> Fruits

Name in Czech

C-Geranyl Compounds from <i>Paulownia tomentosa</i> Fruits

Authors

ŠMEJKAL, Karel (203 Czech Republic), Lenka GRYCOVÁ (203 Czech Republic, belonging to the institution), Radek MAREK (203 Czech Republic, guarantor, belonging to the institution), Filip LEMIERE (56 Belgium), Dagmar JANKOVSKÁ (203 Czech Republic), Hana FOREJTNÍKOVÁ (203 Czech Republic), Ján VANČO (203 Czech Republic) and Václav SUCHÝ (203 Czech Republic)

Edition

Journal of Natural Products, Washington, American Chemical Society, 2007, 0163-3864

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

10406 Analytical chemistry

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 2.551

RIV identification code

RIV/00216224:14310/07:00022177

Organization unit

Faculty of Science

UT WoS

000248978800005

Keywords in English

flavonoid; geranyl; natural product; NMR

Tags

International impact, Reviewed
Změněno: 7/3/2015 09:17, prof. RNDr. Radek Marek, Ph.D.

Abstract

V originále

Five geranylflavonoids, one prenylated flavonoid, and a simple flavanone were isolated from an ethanolic extract of Paulownia tomentosa fruit. Tomentodiplacol (1), 3-O-methyl-5-methoxydiplacol (2), 6-isopentenyl-3-O-methyltaxifolin (3), and dihydrotricin (4) are reported from a natural source for the first time and 3-O-methyldiplacone (6) for the first time from the genus Paulownia. The structures of the compounds were determined by mass spectrometry, including HR-MS, and by 1D and 2D NMR spectroscopy. The cytotoxicity and DPPH (2,2-diphenyl-1-picrylhydrazyl) quenching activity of some of these compounds were tested, with diplacone proving to be the best antioxidant, though the most cytotoxic compound.

In Czech

Five geranylflavonoids, one prenylated flavonoid, and a simple flavanone were isolated from an ethanolic extract of Paulownia tomentosa fruit. Tomentodiplacol (1), 3-O-methyl-5-methoxydiplacol (2), 6-isopentenyl-3-O-methyltaxifolin (3), and dihydrotricin (4) are reported from a natural source for the first time and 3-O-methyldiplacone (6) for the first time from the genus Paulownia. The structures of the compounds were determined by mass spectrometry, including HR-MS, and by 1D and 2D NMR spectroscopy. The cytotoxicity and DPPH (2,2-diphenyl-1-picrylhydrazyl) quenching activity of some of these compounds were tested, with diplacone proving to be the best antioxidant, though the most cytotoxic compound.

Links

LC06030, research and development project
Name: Biomolekulární centrum
Investor: Ministry of Education, Youth and Sports of the CR, Biomolecular centre
MSM0021622413, plan (intention)
Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment