2007
The exosome and RNA quality control in the nucleus
VAŇÁČOVÁ, Štěpánka a Richard ŠTEFLZákladní údaje
Originální název
The exosome and RNA quality control in the nucleus
Název česky
The exosome and RNA quality control in the nucleus
Autoři
VAŇÁČOVÁ, Štěpánka (203 Česká republika, garant) a Richard ŠTEFL (203 Česká republika)
Vydání
EMBO REPORTS, Nature Publishing Group, London, UK, Nature Publishing Group, London, UK, 2007, 1469-221X
Další údaje
Jazyk
angličtina
Typ výsledku
Článek v odborném periodiku
Obor
10600 1.6 Biological sciences
Stát vydavatele
Velká Británie a Severní Irsko
Utajení
není předmětem státního či obchodního tajemství
Impakt faktor
Impact factor: 7.450
Kód RIV
RIV/00216224:14310/07:00022206
Organizační jednotka
Přírodovědecká fakulta
UT WoS
000247651500012
Klíčová slova anglicky
RNA decay; exoribonuclease; exosome; structure; nuclear polyadenylation; TRAMP
Štítky
Příznaky
Mezinárodní význam, Recenzováno
Změněno: 30. 7. 2007 12:21, prof. Mgr. Richard Štefl, Ph.D.
V originále
To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings, the leftovers of RNA processing, but also incorrectly processed RNAs that contain defects. By using this mechanism, cells ensure that only high-quality RNAs are engaged in protein synthesis and other cellular processes. The exosome, a complex of several exoribonucleolytic and RNA-binding proteins, is the central 3'-end RNA degradation and processing factor in this surveillance apparatus. The exosome operates with auxiliary factors that stimulate its activity and recruit its RNA substrates in the crowded cellular environment. In this review, we discuss recent structural and functional data related to the nuclear quality-control apparatus, including the long-awaited structure of the human exosome and its activity.
Česky
To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings, the leftovers of RNA processing, but also incorrectly processed RNAs that contain defects. By using this mechanism, cells ensure that only high-quality RNAs are engaged in protein synthesis and other cellular processes. The exosome, a complex of several exoribonucleolytic and RNA-binding proteins, is the central 3'-end RNA degradation and processing factor in this surveillance apparatus. The exosome operates with auxiliary factors that stimulate its activity and recruit its RNA substrates in the crowded cellular environment. In this review, we discuss recent structural and functional data related to the nuclear quality-control apparatus, including the long-awaited structure of the human exosome and its activity.
Návaznosti
| MSM0021622413, záměr |
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