Detailed Information on Publication Record
2007
The exosome and RNA quality control in the nucleus
VAŇÁČOVÁ, Štěpánka and Richard ŠTEFLBasic information
Original name
The exosome and RNA quality control in the nucleus
Name in Czech
The exosome and RNA quality control in the nucleus
Authors
VAŇÁČOVÁ, Štěpánka (203 Czech Republic, guarantor) and Richard ŠTEFL (203 Czech Republic)
Edition
EMBO REPORTS, Nature Publishing Group, London, UK, Nature Publishing Group, London, UK, 2007, 1469-221X
Other information
Language
English
Type of outcome
Článek v odborném periodiku
Field of Study
10600 1.6 Biological sciences
Country of publisher
United Kingdom of Great Britain and Northern Ireland
Confidentiality degree
není předmětem státního či obchodního tajemství
Impact factor
Impact factor: 7.450
RIV identification code
RIV/00216224:14310/07:00022206
Organization unit
Faculty of Science
UT WoS
000247651500012
Keywords in English
RNA decay; exoribonuclease; exosome; structure; nuclear polyadenylation; TRAMP
Tags
International impact, Reviewed
Změněno: 30/7/2007 12:21, prof. Mgr. Richard Štefl, Ph.D.
V originále
To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings, the leftovers of RNA processing, but also incorrectly processed RNAs that contain defects. By using this mechanism, cells ensure that only high-quality RNAs are engaged in protein synthesis and other cellular processes. The exosome, a complex of several exoribonucleolytic and RNA-binding proteins, is the central 3'-end RNA degradation and processing factor in this surveillance apparatus. The exosome operates with auxiliary factors that stimulate its activity and recruit its RNA substrates in the crowded cellular environment. In this review, we discuss recent structural and functional data related to the nuclear quality-control apparatus, including the long-awaited structure of the human exosome and its activity.
In Czech
To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings, the leftovers of RNA processing, but also incorrectly processed RNAs that contain defects. By using this mechanism, cells ensure that only high-quality RNAs are engaged in protein synthesis and other cellular processes. The exosome, a complex of several exoribonucleolytic and RNA-binding proteins, is the central 3'-end RNA degradation and processing factor in this surveillance apparatus. The exosome operates with auxiliary factors that stimulate its activity and recruit its RNA substrates in the crowded cellular environment. In this review, we discuss recent structural and functional data related to the nuclear quality-control apparatus, including the long-awaited structure of the human exosome and its activity.
Links
| MSM0021622413, plan (intention) |
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