VAŇÁČOVÁ, Štěpánka and Richard ŠTEFL. The exosome and RNA quality control in the nucleus. EMBO REPORTS. Nature Publishing Group, London, UK: Nature Publishing Group, London, UK, 2007, vol. 8, No 7, p. 651-657. ISSN 1469-221X.
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Basic information
Original name The exosome and RNA quality control in the nucleus
Name in Czech The exosome and RNA quality control in the nucleus
Authors VAŇÁČOVÁ, Štěpánka (203 Czech Republic, guarantor) and Richard ŠTEFL (203 Czech Republic).
Edition EMBO REPORTS, Nature Publishing Group, London, UK, Nature Publishing Group, London, UK, 2007, 1469-221X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 10600 1.6 Biological sciences
Country of publisher United Kingdom of Great Britain and Northern Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 7.450
RIV identification code RIV/00216224:14310/07:00022206
Organization unit Faculty of Science
UT WoS 000247651500012
Keywords in English RNA decay; exoribonuclease; exosome; structure; nuclear polyadenylation; TRAMP
Tags exoribonuclease, exosome, nuclear polyadenylation, RNA decay, structure, TRAMP
Tags International impact, Reviewed
Changed by Changed by: prof. Mgr. Richard Štefl, Ph.D., učo 19362. Changed: 30/7/2007 12:21.
Abstract
To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings, the leftovers of RNA processing, but also incorrectly processed RNAs that contain defects. By using this mechanism, cells ensure that only high-quality RNAs are engaged in protein synthesis and other cellular processes. The exosome, a complex of several exoribonucleolytic and RNA-binding proteins, is the central 3'-end RNA degradation and processing factor in this surveillance apparatus. The exosome operates with auxiliary factors that stimulate its activity and recruit its RNA substrates in the crowded cellular environment. In this review, we discuss recent structural and functional data related to the nuclear quality-control apparatus, including the long-awaited structure of the human exosome and its activity.
Abstract (in Czech)
To control the quality of RNA biogenesis in the nucleus, cells use sophisticated molecular machines. These machines recognize and degrade not only RNA trimmings, the leftovers of RNA processing, but also incorrectly processed RNAs that contain defects. By using this mechanism, cells ensure that only high-quality RNAs are engaged in protein synthesis and other cellular processes. The exosome, a complex of several exoribonucleolytic and RNA-binding proteins, is the central 3'-end RNA degradation and processing factor in this surveillance apparatus. The exosome operates with auxiliary factors that stimulate its activity and recruit its RNA substrates in the crowded cellular environment. In this review, we discuss recent structural and functional data related to the nuclear quality-control apparatus, including the long-awaited structure of the human exosome and its activity.
Links
MSM0021622413, plan (intention)Name: Proteiny v metabolismu a při interakci organismů s prostředím
Investor: Ministry of Education, Youth and Sports of the CR, Proteins in metabolism and interaction of organisms with the environment
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