J 2007

Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a case study

PŘIKRYL, Radovan, Simona SKOTÁKOVÁ, Tomáš KAŠPÁREK, Eva ČEŠKOVÁ, Hana KUČEROVÁ et. al.

Basic information

Original name

Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a case study

Name in Czech

Ovlivnění negativních příznaků schizofrenie prostřednictvím repetitivní transkraniální magnetické stimulace: kazuistické sdělení

Name (in English)

Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a case study

Authors

PŘIKRYL, Radovan (203 Czech Republic, guarantor), Simona SKOTÁKOVÁ (203 Czech Republic), Tomáš KAŠPÁREK (203 Czech Republic), Eva ČEŠKOVÁ (203 Czech Republic), Hana KUČEROVÁ (203 Czech Republic) and Libor USTOHAL (203 Czech Republic)

Edition

Acta Neuropsychiatrica, Australia, Blackwell Publishing, 2007, 0924-2708

Other information

Language

Czech

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Czech Republic

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.206

RIV identification code

RIV/00216224:14110/07:00019061

Organization unit

Faculty of Medicine

UT WoS

000245231200008

Keywords in English

negative symptoms; schizophrenia; rTMS

Tags

International impact, Reviewed
Změněno: 19/6/2009 14:02, prof. MUDr. Eva Češková, CSc.

Abstract

V originále

Background: The present trial was designed to investigate the influence of repetitive transcranial magnetic stimulation (rTMS) on negative schizophrenic symptoms using high frequency stimulation of the left dorsolateral prefrontal cortex in a simple blind randomised design. Methods: The study was carried out on a 42-year-old schizophrenic patient (paranoid subtype) with prominent negative symptoms who was firstly treated with sham rTMS during the first three weeks and then with real high frequency during the following three weeks. He was rated before and after the sham and after the real rTMS therapy for positive, negative and depressive symptoms. Results: rTMS was superior to sham treatment in reduction of negative and depressive symptoms. Conclusion: High frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of severity of negative symptoms in a patient with chronic schizophrenia and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.

In English

Background: The present trial was designed to investigate the influence of repetitive transcranial magnetic stimulation (rTMS) on negative schizophrenic symptoms using high frequency stimulation of the left dorsolateral prefrontal cortex in a simple blind randomised design. Methods: The study was carried out on a 42-year-old schizophrenic patient (paranoid subtype) with prominent negative symptoms who was firstly treated with sham rTMS during the first three weeks and then with real high frequency during the following three weeks. He was rated before and after the sham and after the real rTMS therapy for positive, negative and depressive symptoms. Results: rTMS was superior to sham treatment in reduction of negative and depressive symptoms. Conclusion: High frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of severity of negative symptoms in a patient with chronic schizophrenia and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.

Links

MSM0021622404, plan (intention)
Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
NR7986, research and development project
Name: Ovlivnění negativních příznaků schizofrenie pomocí repetitivní transkraniální magnetické stimulace (rTMS) v podmínkách jednoduše slepé, randomizované studie.
Investor: Ministry of Health of the CR