PŘIKRYL, Radovan, Simona SKOTÁKOVÁ, Tomáš KAŠPÁREK, Eva ČEŠKOVÁ, Hana KUČEROVÁ and Libor USTOHAL. Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a case study. Acta Neuropsychiatrica. Australia: Blackwell Publishing, 2007, vol. 19, No 2, p. 53-55. ISSN 0924-2708.
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Basic information
Original name Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a case study
Name in Czech Ovlivnění negativních příznaků schizofrenie prostřednictvím repetitivní transkraniální magnetické stimulace: kazuistické sdělení
Name (in English) Influencing negative symptoms of schizophrenia with repetitive transcranial magnetic stimulation: a case study
Authors PŘIKRYL, Radovan (203 Czech Republic, guarantor), Simona SKOTÁKOVÁ (203 Czech Republic), Tomáš KAŠPÁREK (203 Czech Republic), Eva ČEŠKOVÁ (203 Czech Republic), Hana KUČEROVÁ (203 Czech Republic) and Libor USTOHAL (203 Czech Republic).
Edition Acta Neuropsychiatrica, Australia, Blackwell Publishing, 2007, 0924-2708.
Other information
Original language Czech
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Czech Republic
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.206
RIV identification code RIV/00216224:14110/07:00019061
Organization unit Faculty of Medicine
UT WoS 000245231200008
Keywords in English negative symptoms; schizophrenia; rTMS
Tags negative symptoms, rTMS, schizophrenia
Tags International impact, Reviewed
Changed by Changed by: prof. MUDr. Eva Češková, CSc., učo 726. Changed: 19/6/2009 14:02.
Abstract
Background: The present trial was designed to investigate the influence of repetitive transcranial magnetic stimulation (rTMS) on negative schizophrenic symptoms using high frequency stimulation of the left dorsolateral prefrontal cortex in a simple blind randomised design. Methods: The study was carried out on a 42-year-old schizophrenic patient (paranoid subtype) with prominent negative symptoms who was firstly treated with sham rTMS during the first three weeks and then with real high frequency during the following three weeks. He was rated before and after the sham and after the real rTMS therapy for positive, negative and depressive symptoms. Results: rTMS was superior to sham treatment in reduction of negative and depressive symptoms. Conclusion: High frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of severity of negative symptoms in a patient with chronic schizophrenia and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.
Abstract (in English)
Background: The present trial was designed to investigate the influence of repetitive transcranial magnetic stimulation (rTMS) on negative schizophrenic symptoms using high frequency stimulation of the left dorsolateral prefrontal cortex in a simple blind randomised design. Methods: The study was carried out on a 42-year-old schizophrenic patient (paranoid subtype) with prominent negative symptoms who was firstly treated with sham rTMS during the first three weeks and then with real high frequency during the following three weeks. He was rated before and after the sham and after the real rTMS therapy for positive, negative and depressive symptoms. Results: rTMS was superior to sham treatment in reduction of negative and depressive symptoms. Conclusion: High frequency rTMS applied over the left dorsolateral prefrontal cortex led to a reduction of severity of negative symptoms in a patient with chronic schizophrenia and may be beneficial as an augmentation option to antipsychotics in the treatment of negative symptoms of schizophrenia.
Links
MSM0021622404, plan (intention)Name: Vnitřní organizace a neurobiologické mechanismy funkčních systémů CNS
Investor: Ministry of Education, Youth and Sports of the CR, The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
NR7986, research and development projectName: Ovlivnění negativních příznaků schizofrenie pomocí repetitivní transkraniální magnetické stimulace (rTMS) v podmínkách jednoduše slepé, randomizované studie.
Investor: Ministry of Health of the CR
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