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@inproceedings{720038,
author = {Matějková, Petra and Strouhal, Michal and Šmajs, David and Norris, S. J. and Weinstock, G. M.},
address = {Munich, Germany},
booktitle = {In Abstract Book: 17th European Congress of Clinical Microbiology and Infectous Diseases. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS.},
keywords = {Sequencing; Treponema pallidum ssp. pertenue Samoa D},
language = {eng},
location = {Munich, Germany},
pages = {238-238},
publisher = {European Congress of Clinical Microbiology and Infectous Diseases},
title = {Sequencing of Treponema pallidum ssp. pertenue Samoa D genome.},
year = {2007}
}
TY - JOUR
ID - 720038
AU - Matějková, Petra - Strouhal, Michal - Šmajs, David - Norris, S. J. - Weinstock, G. M.
PY - 2007
TI - Sequencing of Treponema pallidum ssp. pertenue Samoa D genome.
PB - European Congress of Clinical Microbiology and Infectous Diseases
CY - Munich, Germany
KW - Sequencing
KW - Treponema pallidum ssp. pertenue Samoa D
N2 - Although syphilis and yaws have different clinical manifestation, the pathogens are microscopically and serologically indistinguishable. Genome scale approaches (microarray hybridisations and whole genome fingerprinting, WGF) showed that there are no gene deletions and multiplications and no large indels. Relatively subtle genetic differences responsible for different pathogenesis of syphilis and yaws thus require complete genome sequence of TPE. Physical map of complete genome sequence obtained by combination of CGS and DDT of heterologous regions was confirmed by WGF. CGS together with DDT sequencing and WGF was employed to obtain complete genome sequence of TPE Samoa D strain. The unfinished complete genome sequence comprised 1 linear contig. In silico proteome analysis revealed that more than 300 proteins (out of 1039 proteins predicted in TPA Nichols strain) were affected by sequence changes. The genome sequence of yaws treponeme was used to define intersubspecies difference between TPE and TPA.
ER -
MATĚJKOVÁ, Petra, Michal STROUHAL, David ŠMAJS, S. J. NORRIS a G. M. WEINSTOCK. Sequencing of Treponema pallidum ssp. pertenue Samoa D genome. In \textit{In Abstract Book: 17th European Congress of Clinical Microbiology and Infectous Diseases. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS.}. Munich, Germany: European Congress of Clinical Microbiology and Infectous Diseases. s.~238. ISSN~0924-8579. 2007.
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