Interference of N-heterocyclic PAHs with signaling of retinoids

BENÍŠEK, Martin, Jiří PACHERNÍK, Luděk BLÁHA and Klára HILSCHEROVÁ. Interference of N-heterocyclic PAHs with signaling of retinoids. In Abstract Book, SETAC EUROPE 17TH ANNUAL MEETING. 2007.

Basic information

• Original name: Interference of N-heterocyclic PAHs with signaling of retinoids
• Name in Czech: Vliv N-heterocyklických PAHs na signálování retinoidů
• Authors: BENÍŠEK, Martin (203 Czech Republic, belonging to the institution), Jiří PACHERNÍK (203 Czech Republic, belonging to the institution), Luděk BLÁHA (203 Czech Republic, belonging to the institution) and Klára HILSCHEROVÁ (203 Czech Republic, guarantor, belonging to the institution).
• Edition: Abstract Book, SETAC EUROPE 17TH ANNUAL MEETING, 2007.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30304 Public and environmental health
• Country of publisher: Portugal
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14310/07:00020348
• Organization unit: Faculty of Science
• Keywords in English: retinoid; N-PAHs; in vitro
• Tags: in vitro, N-PAHs, retinoid
• Tags: International impact

Abstract

N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potencies and bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed and quantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160.

Abstract (in Czech)

N-heterocyclic analogs of PAHs (N-PAHs) are as well as homocyclic PAHs important and widespread environmental contaminants. Many of them are carcinogens, mutagens and teratogens. Some results indicate that N-PAHs have higher toxic and genotoxic potencies and bioavailability than PAHs. In this study the interference of N-PAHs with retinoid signaling system was tested. After 24 h exposure most of three, four and five ring PAHs and N-PAHs increased RA activity. Obtained data were statistically analyzed and quantitative-structure activity relationship study was performed. This study was supported by GACR 525/05/P160.

Links

• GP525/05/P160, research and development project: Name: In vitro modely pro studium endokrinní disrupce - účinky tradičních a nových typů persistentních organických polutantů

Investor: Czech Science Foundation, In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)