AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT?

BITTNER, Michal, Klára HILSCHEROVÁ and John, Paul GIESY. AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT? In Humic Science and Technology Ten - Book of Abstracts. 2007.

Basic information

Original name

AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT?

Name in Czech

AhR-aktivní huminové látky - nebezpečí či prospěch

Authors

BITTNER, Michal (203 Czech Republic, guarantor, belonging to the institution), Klára HILSCHEROVÁ (203 Czech Republic, belonging to the institution) and John, Paul GIESY (840 United States of America)

Edition

Humic Science and Technology Ten - Book of Abstracts, 2007

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Other information

Language

English

Type of outcome

Konferenční abstrakt

Field of Study

30304 Public and environmental health

Country of publisher

United States of America

Confidentiality degree

není předmětem státního či obchodního tajemství

RIV identification code

RIV/00216224:14310/07:00020349

Organization unit

Faculty of Science

Keywords in English

Humic substances; Ah receptor; Irradiation

Tags

Ah Receptor, Humic substances, irradiation

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Abstract

V originále

Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested6. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. General toxicological principles suggest that partial agonists should antagonize action of full agonists; nevertheless our results have shown more likely contradictory effect. Supposed environmental consequences of our findings will be discussed.

In Czech

Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested6. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. General toxicological principles suggest that partial agonists should antagonize action of full agonists; nevertheless our results have shown more likely contradictory effect. Supposed environmental consequences of our findings will be discussed.

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Links

GP525/05/P160, research and development project	Name: In vitro modely pro studium endokrinní disrupce - účinky tradičních a nových typů persistentních organických polutantů Investor: Czech Science Foundation, In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants
MSM0021622412, plan (intention)	Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL) Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)