AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT?
BITTNER, Michal, Klára HILSCHEROVÁ and John, Paul GIESY. AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT? In Humic Science and Technology Ten - Book of Abstracts. 2007. |
Other formats:
BibTeX
LaTeX
RIS
|
Basic information | |
---|---|
Original name | AhR-ACTIVE HUMIC SUBSTANCES - DANGER OR BENEFIT? |
Name in Czech | AhR-aktivní huminové látky - nebezpečí či prospěch |
Authors | BITTNER, Michal (203 Czech Republic, guarantor, belonging to the institution), Klára HILSCHEROVÁ (203 Czech Republic, belonging to the institution) and John, Paul GIESY (840 United States of America). |
Edition | Humic Science and Technology Ten - Book of Abstracts, 2007. |
Other information | |
---|---|
Original language | English |
Type of outcome | Conference abstract |
Field of Study | 30304 Public and environmental health |
Country of publisher | United States of America |
Confidentiality degree | is not subject to a state or trade secret |
RIV identification code | RIV/00216224:14310/07:00020349 |
Organization unit | Faculty of Science |
Keywords in English | Humic substances; Ah receptor; Irradiation |
Tags | Ah Receptor, Humic substances, irradiation |
Changed by | Changed by: prof. RNDr. Luděk Bláha, Ph.D., učo 15473. Changed: 27/4/2011 12:36. |
Abstract |
---|
Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested6. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. General toxicological principles suggest that partial agonists should antagonize action of full agonists; nevertheless our results have shown more likely contradictory effect. Supposed environmental consequences of our findings will be discussed. |
Abstract (in Czech) |
---|
Using in vitro bioassay, we have found significant AhR-mediated activities of four out of twelve HS tested6. Applied bioassay is based on H4IIE-luc cells (rat hepatoma) stably transfected with a luciferase reporter gene under the control of dioxin-responsive element. In recent contribution, we summarize our new findings on interaction of AhR-active HS, being partial agonists of AhR, with full agonists of AhR, e.g. 2,3,7,8-TCDD. General toxicological principles suggest that partial agonists should antagonize action of full agonists; nevertheless our results have shown more likely contradictory effect. Supposed environmental consequences of our findings will be discussed. |
Links | |
---|---|
GP525/05/P160, research and development project | Name: In vitro modely pro studium endokrinní disrupce - účinky tradičních a nových typů persistentních organických polutantů |
Investor: Czech Science Foundation, In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants | |
MSM0021622412, plan (intention) | Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL) |
Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) |
PrintDisplayed: 13/10/2024 06:50