HMGB1 associates with TERT and stimulates telomerase activity
| KUNICKÁ, Zuzana, Eva POLANSKÁ, Martina DVOŘÁČKOVÁ, Michal ŠTROS and Jiří FAJKUS. HMGB1 associates with TERT and stimulates telomerase activity. In Telomeres & Telomerase. 2007. |
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| Basic information | |
|---|---|
| Original name | HMGB1 associates with TERT and stimulates telomerase activity |
| Name in Czech | HMGB1 asociuje s TERT a stimuluje aktivitu telomerázy |
| Authors | KUNICKÁ, Zuzana (203 Czech Republic), Eva POLANSKÁ (203 Czech Republic), Martina DVOŘÁČKOVÁ (203 Czech Republic), Michal ŠTROS (203 Czech Republic) and Jiří FAJKUS (203 Czech Republic, guarantor). |
| Edition | Telomeres & Telomerase, 2007. |
| Other information | |
|---|---|
| Original language | English |
| Type of outcome | Conference abstract |
| Field of Study | Genetics and molecular biology |
| Country of publisher | United States of America |
| Confidentiality degree | is not subject to a state or trade secret |
| RIV identification code | RIV/00216224:14310/07:00019418 |
| Organization unit | Faculty of Science |
| Keywords in English | telomere; chromatin; high-mobility-group protein |
| Tags | chromatin, high-mobility-group protein, telomere |
| Tags | International impact |
| Changed by | Changed by: prof. RNDr. Jiří Fajkus, CSc., učo 28574. Changed: 9/4/2010 13:08. |
| Abstract |
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| The lack of HMGB1 in MEF cells results in significant decrease in telomerase activity, the increase of telomere heterogeneity and increased frequency of chromosomal aberrations. |
| Abstract (in Czech) |
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| Ztráta HMGB1 v MEF buňkách způsobuje výrazné snížení aktivity telomerázy, zvýšení heterogenity telomer a zvýšený výskyt chromosomových aberací |
| Links | |
|---|---|
| AV0Z50040507, plan (intention) | Name: Biofyzika dynamických struktur a funkcí biologických systémů |
| GA204/05/2031, research and development project | Name: Objasnění vlivu HMGB1 na funkci nádorově supresorových proteinů a telomer |
| GA521/05/0055, research and development project | Name: Molekulární evoluce a funkční analýza komponent rostlinných telomer a telomeráz |
| MSM0021622415, plan (intention) | Name: Molekulární podstata buněčných a tkáňových regulací |
| Investor: Ministry of Education, Youth and Sports of the CR, Molecular basis of cell and tissue regulations | |
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