Homocysteine, folate and vitamin B12 in seminal plasma

CRHA, Igor, Jitka MELOUNOVÁ, Michaela KRÁLÍKOVÁ, Jaroslava TALLOVÁ, Jiří JARKOVSKÝ, Jana ŽÁKOVÁ and Pavel VENTRUBA. Homocysteine, folate and vitamin B12 in seminal plasma. 2007.

Basic information

• Original name: Homocysteine, folate and vitamin B12 in seminal plasma
• Name in Czech: Homocystein, folát a vitamin B12 v seminální plasmě
• Authors: CRHA, Igor (203 Czech Republic, guarantor, belonging to the institution), Jitka MELOUNOVÁ (203 Czech Republic, belonging to the institution), Michaela KRÁLÍKOVÁ (203 Czech Republic, belonging to the institution), Jaroslava TALLOVÁ (203 Czech Republic, belonging to the institution), Jiří JARKOVSKÝ (203 Czech Republic, belonging to the institution), Jana ŽÁKOVÁ (203 Czech Republic, belonging to the institution) and Pavel VENTRUBA (203 Czech Republic, belonging to the institution).
• Edition: 2007.

Other information

• Original language: English
• Type of outcome: Conference abstract
• Field of Study: 30214 Obstetrics and gynaecology
• Country of publisher: Czech Republic
• Confidentiality degree: is not subject to a state or trade secret
• RIV identification code: RIV/00216224:14110/07:00041490
• Organization unit: Faculty of Medicine
• UT WoS: 000255322200543
• Keywords in English: homocysteine; folate; reproduction; seminal plasma
• Tags: folate, homocysteine, reproduction, seminal plasma
• Tags: International impact, Reviewed

Abstract

Elevated plasma homocysteine is an independent risk factor for the development of many pathological states, but at present, there is only little information about its concentration in seminal fluid. It is also well known that folate plays an important role in the reproduction and that the treatment with folate antagonists impairs the reproductive functions in men. A previous study found that low seminal plasma folate concentrations are associated with low sperm density and sperm count and that folate concentrations in the seminal fluid correlate with blood plasma folate and homocysteine. The homocysteine, vitamin B12 and folate concentrations were significantly higher in men with normospermia than in men with azoospermia and oligoasthenospermia. Negative correlation between folate and homocystein in normospermia group was found. Low levels of homocysteine in the group with azoospermia may indicate decreased metabolic activity in the testes of these men.

Abstract (in Czech)

Koncentrace homocysteinu, vitaminu B12 a folátu byly signifikantně vyšší u mužů s normospermií než u mužů s azoospermií a oligoasthenospermií. Byla prokázána negativní korelace mezi folátem a homocysteinem u mužů s normoseprmií. Nízké hladiny homocysteinu u mužů s azoospermií svědčí pro sníženou metabolickou aktivitu testikulární tkáně.

Links

• MSM0021622412, plan (intention): Name: Interakce mezi chemickými látkami, prostředím a biologickými systémy a jejich důsledky na globální, regionální a lokální úrovni (INCHEMBIOL) (Acronym: INCHEMBIOL)

Investor: Ministry of Education, Youth and Sports of the CR, Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL)