BENEŠOVÁ, Yvonne, Michal BERÁNEK, Magdaléna HLADÍKOVÁ, Jiří VÁCHA, Zdeněk KADAŇKA and Anna VAŠKŮ. Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes polymorphisms in multiple sclerosis. Journal of Neurology. Darmstadt: Steinkopff Verlag, 2007, Volume 254, May 2007, p. III/68-III/68, 1 pp. ISSN 0340-5354. |
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@article{721525, author = {Benešová, Yvonne and Beránek, Michal and Hladíková, Magdaléna and Vácha, Jiří and Kadaňka, Zdeněk and Vašků, Anna}, article_location = {Darmstadt}, article_number = {May 2007}, keywords = {multiple sclerosis;MMP-2;TIMP-2 genes polymorphisms}, language = {eng}, issn = {0340-5354}, journal = {Journal of Neurology}, title = {Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes polymorphisms in multiple sclerosis.}, volume = {Volume 254}, year = {2007} }
TY - JOUR ID - 721525 AU - Benešová, Yvonne - Beránek, Michal - Hladíková, Magdaléna - Vácha, Jiří - Kadaňka, Zdeněk - Vašků, Anna PY - 2007 TI - Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes polymorphisms in multiple sclerosis. JF - Journal of Neurology VL - Volume 254 IS - May 2007 SP - III/68-III/68 EP - III/68-III/68 PB - Steinkopff Verlag SN - 03405354 KW - multiple sclerosis;MMP-2;TIMP-2 genes polymorphisms N2 - Multiple sclerosis (MS) is a multifactorial, polygenic disease. Matrix metalloproteinases (MMPs) play an important role in the immunopathogenesis and progression of MS.The aim of this study was to examine possible association among polymorphisms in gene promotor region for MMP-2 (-168G/T, -735C/T, -790T/G, -1306C/T) and TIMP-2 (+853 G/A, -418 G/C) with multiple sclerosis. Methods: A sample of 221 patients with multiple sclerosis was compared to 118 healthy subjects.The DNA genotyping was performed using PCR methods with restriction analyses.According to our results, distribution of polymorphisms in MMP-2 (-735C/T) and TIMP-2 (+853)G/A gene are associated with higher risk for relapsing-remitting multiple sclerosis clinical manifestation. ER -
BENEŠOVÁ, Yvonne, Michal BERÁNEK, Magdaléna HLADÍKOVÁ, Jiří VÁCHA, Zdeněk KADAŇKA and Anna VAŠKŮ. Matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 genes polymorphisms in multiple sclerosis. \textit{Journal of Neurology}. Darmstadt: Steinkopff Verlag, 2007, Volume 254, May 2007, p.~III/68-III/68, 1 pp. ISSN~0340-5354.
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