Psychotherapy alone or in combination with pharmacotherapy is according to contemporary knowledge effective in treatment of depressive disorder and represents awailable possibility of increasing efectivity of treatment of depression. This article is meant to contribute to the transparency of the spectrum of psychotherapeutic approaches to depression. Five main psychotherapeutic approaches used with the treatment of depression are described here, the focus is on their practical application in clinical practice. It is psychodynamic psychotherapy, cognitive behavioral therapy, systemic family therapy and humanistic psychotherapy (with focus on Gestalt therapy). Evidence of efectiveness and case study is attached to the description of every approach. Combination of psychotherapy and pharmacotherapy is also described here. Finaly the contact points of different psychotherapeutic approaches are mentioned and a possible future direction of complex treatment of depression is outlined.