KALA, Zdeněk, Vlastimil VÁLEK and Petr KYSELA. Amyloidosis of the small intestine. European journal of radiology. Ireland: Elsevier Science Ireland Ltd, 2007, vol. 63, No 1, p. 105-9, 5 pp. ISSN 0720-048X.
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Basic information
Original name Amyloidosis of the small intestine.
Name in Czech Amyloidóza tenkého střeva
Authors KALA, Zdeněk (203 Czech Republic, guarantor), Vlastimil VÁLEK (203 Czech Republic) and Petr KYSELA (203 Czech Republic).
Edition European journal of radiology, Ireland, Elsevier Science Ireland Ltd, 2007, 0720-048X.
Other information
Original language English
Type of outcome Article in a journal
Field of Study 30000 3. Medical and Health Sciences
Country of publisher Ireland
Confidentiality degree is not subject to a state or trade secret
Impact factor Impact factor: 1.915
RIV identification code RIV/00216224:14110/07:00032287
Organization unit Faculty of Medicine
UT WoS 000248058800015
Keywords in English small intestine;tumor; amyloidosis;enteroclysis;ultrasound;ischemic enteritis
Tags amyloidosis, Enteroclysis, ischemic enteritis, small intestine, Tumor, ultrasound
Tags International impact
Changed by Changed by: Ing. Blanka Přikrylová, učo 71313. Changed: 12/4/2010 22:53.
Abstract
Amyloidosis is a rare disease characterized by forming pathological protein deposits - amyloid - in many organs and tissues. This decreases their functionality. The aim of this small study was to determine, whether the radiological picture of the small intestine involvement in amyloidosis is in some sense specific as sometimes described in literature giving rise to high suspicion for the disease in symptomatic patients. MATERIAL AND METHODS: The prospective study comprising seven patients hospitalized in surgical department is presented together with a survey on the disease, its appearance in radiological imaging. All patients underwent abdominal ultrasound (ATL 5000 HDI, 7-12MHz linear probe, no contrast enhancement, supine position), abdominal CT (Somatom Plus, Siemens, single detector, conventional abdominal CT protocol) and enteroclysis (Micropaque suspension 300ml, application rate of 75ml/min, dilution with HP-7000 being 1:1 and HP-7000 solution 2000ml, application rate of 120ml/min.). RESULTS: The amyloid deposits in the small intestine could be visualized in five of seven patients with the disease. Enteroclysis revealed a diffuse slowed down intestinal motility with an obstruction-like picture in all of our seven patients. The intestinal secretion was normal, plicae were getting polyp-like shape in five of them forming so called "thumb printing" picture. CT showed thickening of the intestinal wall due to deposits with poor blood supply and contrast retention in five of seven patients. Ultrasound visualized thickened, hypoechoic nodular plicae and slowed down motility in these five patients. The most striking finding was the pathological deposits in the intestinal wall were highly hypo-vascular. However, this picture is very similar to that of ischemic enteritis. All seven patients had proven amyloid deposits from bioptic specimens. CONCLUSION: The diagnosis of amyloidosis must be supported by bioptic examination as it has no pathognomic radiological picture. Nevertheless, it allows usually to rise a high suspicion for this and sometimes even guess the type of the pathological protein involved. This can start a search for the primary reason of possible amyloidosis and thus perhaps spear the patients quality of life.
Abstract (in Czech)
Amyloidóza je vzácné onemocnění charakterizovnaé tvorbou depozit patologického proteinu. To snižuje funkci postižených orgánů. Tato práce rozebírá radiologický obraz tohoto onemocnění. Formou prospektivní studie je hodnocen nález u 7 pacientů hospitalizovaných na chirurgii pro potíže s pasáží GIT. U všech bylo provedeno UZ střev a enteroklýza. Bylo provedeno srovnání obrazů jednotlivých metod s výsledkem bioptického vyšetření, které prokázalo určitou specificitu jednotlivých radiologických obrazů. Zobrazovací metody pak u symtpomatických pacientů mohou vyslovit vysoký stupeň podezření na postižení amyloidem.
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