Brachytherapy and percutaneous stenting in the treatment of
cholangiocarcinoma: a prospective randomised study.

J 2007

Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study.

VÁLEK, Vlastimil, Petr KYSELA, Zdeněk KALA, Igor KISS, Jiří TOMÁŠEK et. al.

Basic information

Original name

Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study.

Name in Czech

Brachyterapie a perkutánní stenting v léčbě cholangiokarcinomu. prospektivní studie

Authors

VÁLEK, Vlastimil (203 Czech Republic, guarantor), Petr KYSELA (203 Czech Republic), Zdeněk KALA (203 Czech Republic), Igor KISS (203 Czech Republic), Jiří TOMÁŠEK (203 Czech Republic) and Jiří PETERA (203 Czech Republic)

Edition

European journal of radiology, Ireland, Elsevier Science Ireland Ltd, 2007, 0720-048X

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30000 3. Medical and Health Sciences

Country of publisher

Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.915

RIV identification code

RIV/00216224:14110/07:00032290

Organization unit

Faculty of Medicine

UT WoS

000246613700006

Keywords in English

brachytherapy;biliary stent;cholangiocarcinoma; treatment

Abstract

ORIG CZ

V originále

PURPOSE: To evaluate the effect of radiation therapy including intraluminal brachyterapy with iridium-192 on survival of patients with malignant biliary strictures (cholangiocarcinoma, histologically improved) treated with metallic stent in a prospective randomised study. METHOD AND MATERIALS: In the prospective randomised study, 21 patients with cholangiocarcinoma were treated with implantation of percutaneous stents followed with intraluminal Ir-192 brachytherapy (mean dose 30 Gy) and external radiotherapy (mean dose 50 Gy) and 21 patients were treated only with stents insertion. We did not find any statistically significant differences in age and tumor localization between these two groups of patients. RESULTS: All the patients died. In the group of patients treated with brachytherapy and with stent implantation, the mean survival time was 387.9 days. In the group of patients treated only with stent insertion the mean survival was 298 days. In effort to eliminate possible effect of external radiotherapy we treated the control group of eight patients with cholangiocarcinoma by stent insertion and brachyterapy only. CONCLUSION: Our results show that combined radiation therapy could extend the survival in the patients with cholangiocarcinoma obstruction.

In Czech

Prospektivní randomizovaná studie prokazující přízivý efekt kombinace lokální endoluminální radioterapie s implantaci kovového stentu u pacientů s cholengiocelulárním karcinomem na přežití.

Citovat

VÁLEK, Vlastimil, Petr KYSELA, Zdeněk KALA, Igor KISS, Jiří TOMÁŠEK and Jiří PETERA. Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study. European journal of radiology. Ireland: Elsevier Science Ireland Ltd, 2007, vol. 62, No 2, p. 175-9, 5 pp. ISSN 0720-048X.

@article{721875,
   author = {Válek, Vlastimil and Kysela, Petr and Kala, Zdeněk and Kiss, Igor and Tomášek, Jiří and Petera, Jiří},
   article_location = {Ireland},
   article_number = {2},
   keywords = {brachytherapy;biliary stent;cholangiocarcinoma; treatment},
   language = {eng},
   issn = {0720-048X},
   journal = {European journal of radiology},
   title = {Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study.},
   volume = {62},
   year = {2007}
}

TY  - JOUR
ID  - 721875
AU  - Válek, Vlastimil - Kysela, Petr - Kala, Zdeněk - Kiss, Igor - Tomášek, Jiří - Petera, Jiří
PY  - 2007
TI  - Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study.
JF  - European journal of radiology
VL  - 62
IS  - 2
SP  - 175-9
EP  - 175-9
PB  - Elsevier Science Ireland Ltd
SN  - 0720048X
KW  - brachytherapy;biliary stent;cholangiocarcinoma
KW  - treatment
N2  - PURPOSE: To evaluate the effect of radiation therapy including intraluminal brachyterapy with iridium-192 on survival of patients with malignant biliary strictures (cholangiocarcinoma, histologically improved) treated with metallic stent in a prospective randomised study. METHOD AND MATERIALS: In the prospective randomised study, 21 patients with cholangiocarcinoma were treated with implantation of percutaneous stents followed with intraluminal Ir-192 brachytherapy (mean dose 30 Gy) and external radiotherapy (mean dose 50 Gy) and 21 patients were treated only with stents insertion. We did not find any statistically significant differences in age and tumor localization between these two groups of patients. RESULTS: All the patients died. In the group of patients treated with brachytherapy and with stent implantation, the mean survival time was 387.9 days. In the group of patients treated only with stent insertion the mean survival was 298 days. In effort to eliminate possible effect of external radiotherapy we treated the control group of eight patients with cholangiocarcinoma by stent insertion and brachyterapy only. CONCLUSION: Our results show that combined radiation therapy could extend the survival in the patients with cholangiocarcinoma obstruction.
ER  -

VÁLEK, Vlastimil, Petr KYSELA, Zdeněk KALA, Igor KISS, Jiří TOMÁŠEK and Jiří PETERA. Brachytherapy and percutaneous stenting in the treatment of cholangiocarcinoma: a prospective randomised study. \textit{European journal of radiology}. Ireland: Elsevier Science Ireland Ltd, 2007, vol.~62, No~2, p.~175-9, 5 pp. ISSN~0720-048X.

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