| NOVÁKOVÁ, Marie, Viera BRUDEROVÁ, Zdena SULOVÁ, Juraj KOPÁČEK, Ľubica LACINOVÁ, Richard KVETŇANSKÝ, Anna VAŠKŮ, Peter KAPLAN, Olga KRIŽANOVÁ and Dana JURKOVIČOVÁ. Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions. General Physiology and Biophysics. Bratislava: Slovak Academy of Sciences, 2007, vol. 26, No 2, p. 110-117. ISSN 0231-5882. |
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@article{723519,
author = {Nováková, Marie and Bruderová, Viera and Sulová, Zdena and Kopáček, Juraj and Lacinová, Ľubica and Kvetňanský, Richard and Vašků, Anna and Kaplan, Peter and Križanová, Olga and Jurkovičová, Dana},
article_location = {Bratislava},
article_number = {2},
keywords = {Sigma receptors;IP3 receptors;Stress;Gene expression},
language = {eng},
issn = {0231-5882},
journal = {General Physiology and Biophysics},
title = {Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions},
volume = {26},
year = {2007}
}
TY - JOUR
ID - 723519
AU - Nováková, Marie - Bruderová, Viera - Sulová, Zdena - Kopáček, Juraj - Lacinová, Ľubica - Kvetňanský, Richard - Vašků, Anna - Kaplan, Peter - Križanová, Olga - Jurkovičová, Dana
PY - 2007
TI - Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions
JF - General Physiology and Biophysics
VL - 26
IS - 2
SP - 110-117
EP - 110-117
PB - Slovak Academy of Sciences
SN - 02315882
KW - Sigma receptors;IP3 receptors;Stress;Gene expression
N2 - The aim of the present work was to study the effect of various stressors (hypoxia, cold, immobilization) on the gene expression of sigma receptors in the left ventricles of rat heart. We have clearly shown that gene expression of sigma receptors is upregulated by strong stress stimuli, such as immobilization and/or hypoxia. Nevertheless, cold as a milder stressor has no effect on sigma receptors mRNA levels. Signalling cascade of sigma receptors is dependent on IP3 receptors, since silencing of both, type 1 and 2 IP3 receptors resulted in decreased mRNA levels of sigma receptors. Physiological relevance of sigma receptors in the heart is not clear yet. Nevertheless, based on the already published data we can assume that sigma receptors might participate in contractile responses in cardiomyocytes.
ER -
NOVÁKOVÁ, Marie, Viera BRUDEROVÁ, Zdena SULOVÁ, Juraj KOPÁČEK, Ľubica LACINOVÁ, Richard KVETŇANSKÝ, Anna VAŠKŮ, Peter KAPLAN, Olga KRIŽANOVÁ and Dana JURKOVIČOVÁ. Modulation of expression of the sigma receptors in the heart of rat and mouse in normal and pathological conditions. \textit{General Physiology and Biophysics}. Bratislava: Slovak Academy of Sciences, 2007, vol.~26, No~2, p.~110-117. ISSN~0231-5882.
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