Large-scale Microarray Analysis of Protein and mRNA Level Changes in HL-60 Cells

ŠIMARA, Pavel, Irena KOUTNÁ, Stanislav STEJSKAL, Martina PETERKOVÁ, Petr KRONTORÁD and Zdeněk RUČKA. Large-scale Microarray Analysis of Protein and mRNA Level Changes in HL-60 Cells. 2007.

Basic information

Original name

Large-scale Microarray Analysis of Protein and mRNA Level Changes in HL-60 Cells

Name in Czech

Genomická a proteomická analýza buněk HL-60 pomocí microarray technologie.

Authors

ŠIMARA, Pavel (203 Czech Republic, guarantor, belonging to the institution), Irena KOUTNÁ (203 Czech Republic, belonging to the institution), Stanislav STEJSKAL (203 Czech Republic, belonging to the institution), Martina PETERKOVÁ (203 Czech Republic, belonging to the institution), Petr KRONTORÁD (203 Czech Republic, belonging to the institution) and Zdeněk RUČKA (203 Czech Republic)

Edition

2007

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Other information

Language

English

Type of outcome

Audiovizuální tvorba

Field of Study

10601 Cell biology

Country of publisher

United Kingdom of Great Britain and Northern Ireland

Confidentiality degree

není předmětem státního či obchodního tajemství

References:

URL

RIV identification code

RIV/00216224:14330/07:00022540

Organization unit

Faculty of Informatics

Keywords in English

HL-60; microarrays

Tags

HL-60, microarrays

Tags

International impact

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Abstract

V originále

In this study we compare methods for large-scale microarray analysis of protein and RNA level changes in HL-60 cells, responding to differentiation stimuli. Using microarrays we have found, that level of several proteins was either up- or down-regulated after cell differentiation. In some cases there was significant correlation with appropriate genes.

In Czech

V této studii porovnáváme genomický a proteomický profil buněk HL-60.

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Links

MSM0021622430, plan (intention)	Name: Funkční a molekulární charakteristiky nádorových a normálních kmenových buněk - identifikace cílů pro nová terapeutika a terapeutické strategie Investor: Ministry of Education, Youth and Sports of the CR, Functional and molecular characteristics of cancer and normal stem cells - identification of targets for novel therapeutics and therapeutic strategies
2B06052, research and development project	Name: Vytipování markerů, screening a časná diagnostika nádorových onemocnění pomocí vysoce automatizovaného zpracování multidimenzionálních biomedicínských obrazů (Acronym: Biomarker) Investor: Ministry of Education, Youth and Sports of the CR, Determination of markers, screening and early diagnostics of cancer diseases using highly automated processing of multidimensional biomedical images