| SANCHEZ-PEDREGAL, Victor M, Karel KUBÍČEK, Jens MEILER, Isabelle LYOTHIER, Ian PATERSON a Teresa CARLOMAGNO. The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide. Angewandte Chemie International Edition. Weinheim: Wiley-VCH Verlag GmbH & Co., roč. 45, č. 44, s. 7388-7394. ISSN 1433-7851. 2006. |
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@article{724892,
author = {SanchezandPedregal, Victor M and Kubíček, Karel and Meiler, Jens and Lyothier, Isabelle and Paterson, Ian and Carlomagno, Teresa},
article_location = {Weinheim},
article_number = {44},
keywords = {conformation analysis; discodermolide; NMR spectroscopy; structure-activity relationships; tubulin},
language = {eng},
issn = {1433-7851},
journal = {Angewandte Chemie International Edition},
title = {The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide},
url = {http://www3.interscience.wiley.com/cgi-bin/abstract/113394631/ABSTRACT?CRETRY=1&SRETRY=0},
volume = {45},
year = {2006}
}
TY - JOUR
ID - 724892
AU - Sanchez-Pedregal, Victor M - Kubíček, Karel - Meiler, Jens - Lyothier, Isabelle - Paterson, Ian - Carlomagno, Teresa
PY - 2006
TI - The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide
JF - Angewandte Chemie International Edition
VL - 45
IS - 44
SP - 7388-7394
EP - 7388-7394
PB - Wiley-VCH Verlag GmbH & Co.
SN - 14337851
KW - conformation analysis
KW - discodermolide
KW - NMR spectroscopy
KW - structure-activity relationships
KW - tubulin
UR - http://www3.interscience.wiley.com/cgi-bin/abstract/113394631/ABSTRACT?CRETRY=1&SRETRY=0
N2 - Bound to have similarities: Although the overall shape of discodermolide bound to tubulin resembles the structure of the free ligand, the precise conformation and orientation of the lactone ring are different. A partially overlapping pharmacophore model supported by protein-mediated interligand NOE signals is proposed to explain the similar (but not fully equivalent) biological activity of discodermolide and epothilone A.
ER -
SANCHEZ-PEDREGAL, Victor M, Karel KUBÍČEK, Jens MEILER, Isabelle LYOTHIER, Ian PATERSON a Teresa CARLOMAGNO. The tubulin-bound conformation of discodermolide derived by NMR studies in solution supports a common pharmacophore model for epothilone and discodermolide. \textit{Angewandte Chemie International Edition}. Weinheim: Wiley-VCH Verlag GmbH \&{} Co., roč.~45, č.~44, s.~7388-7394. ISSN~1433-7851. 2006.
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