REESE, Marcel, Victor M SANCHEZ-PEDREGAL, Karel KUBÍČEK, Jens MEILER, Marcel J BLOMMERS, Christian GRIESINGER and Teresa CARLOMAGNO. Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. Angewandte Chemie International Edition. Weinheim: Wiley-VCH Verlag GmbH & Co., 2007, vol. 46, No 11, p. 1864-1868. ISSN 1433-7851. |
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@article{724898, author = {Reese, Marcel and SanchezandPedregal, Victor M and Kubíček, Karel and Meiler, Jens and Blommers, Marcel J and Griesinger, Christian and Carlomagno, Teresa}, article_location = {Weinheim}, article_number = {11}, keywords = {epothilones; NMR spectroscopy; structure elucidation; structure-activity relationships; tubulins}, language = {eng}, issn = {1433-7851}, journal = {Angewandte Chemie International Edition}, title = {Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution}, url = {http://www3.interscience.wiley.com/cgi-bin/abstract/114109930/ABSTRACT}, volume = {46}, year = {2007} }
TY - JOUR ID - 724898 AU - Reese, Marcel - Sanchez-Pedregal, Victor M - Kubíček, Karel - Meiler, Jens - Blommers, Marcel J - Griesinger, Christian - Carlomagno, Teresa PY - 2007 TI - Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution JF - Angewandte Chemie International Edition VL - 46 IS - 11 SP - 1864-1868 EP - 1864-1868 PB - Wiley-VCH Verlag GmbH & Co. SN - 14337851 KW - epothilones KW - NMR spectroscopy KW - structure elucidation KW - structure-activity relationships KW - tubulins UR - http://www3.interscience.wiley.com/cgi-bin/abstract/114109930/ABSTRACT N2 - Fits in a pocket: The binding mode of epothilone A (EpoA) to tubulin is determined by NMR spectroscopy in aqueous solution. The results explain the existing structure-activity relationship data for epothilones with both native and mutant tubulins, and support the existence of a common pharmacophore for EpoA and paclitaxel. ER -
REESE, Marcel, Victor M SANCHEZ-PEDREGAL, Karel KUBÍČEK, Jens MEILER, Marcel J BLOMMERS, Christian GRIESINGER and Teresa CARLOMAGNO. Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution. \textit{Angewandte Chemie International Edition}. Weinheim: Wiley-VCH Verlag GmbH \&{} Co., 2007, vol.~46, No~11, p.~1864-1868. ISSN~1433-7851.
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