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@inproceedings{724988,
author = {Krejčířová, Lenka and Horký, Drahomír and Lauschová, Irena and Doubek, Michael and Mayer, Jiří and Doubek, Jaromír},
address = {Hradec Králové},
booktitle = {Sborník abstrakt41.symposia české anatomické společnosti s mezinárodní účastí},
keywords = {kidney rat amphotericin B deoxycholate amphotericin B colloidal dispersion},
location = {Hradec Králové},
isbn = {80-239-1412-X},
pages = {33-33},
publisher = {Reklamní agentura Hradec Králové},
title = {The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate},
year = {2003}
}
TY - JOUR
ID - 724988
AU - Krejčířová, Lenka - Horký, Drahomír - Lauschová, Irena - Doubek, Michael - Mayer, Jiří - Doubek, Jaromír
PY - 2003
TI - The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate
PB - Reklamní agentura Hradec Králové
CY - Hradec Králové
SN - 802391412X
KW - kidney rat amphotericin B deoxycholate amphotericin B colloidal dispersion
N2 - Amphotericin B (AmB) is used in clinics despite its nephrotoxicity because it remains one of the most efficacious agents currently available for treatment of systemic fungal infections. Amphotericin B colloidal dispersion (ABCD) in addition to the conventional AmB deoxycholate is used in clinics. The goal of our study was to compare the morphology changes of a nephron in the rat after administration of ABCD and AmB. Preliminary clinic study did not show significant differences. Laboratory male rats (pathogen – free, source Anlab, Pratur, Czech Republic), 265-350 g of weight, were used as an experimental model. Two groups of animals were established: group 1 rats were treated with AmB deoxycholate ( Amphotericin B Squibb , Bristol-Myers Squibb,mg/kg of body weight daily for period of 14 days), in group 2 were animals treated with ABCD ( Amphocil, Torrex Pharma, 12 mg/kg of body weight daily for a period of 14 days). Rats were sacrificed and the kidneys were processed for light and elektron microscopy. It was executed also the morphometric study.
ER -
KREJČÍŘOVÁ, Lenka, Drahomír HORKÝ, Irena LAUSCHOVÁ, Michael DOUBEK, Jiří MAYER a Jaromír DOUBEK. The morphology changes in rats kidney after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate. In \textit{Sborník abstrakt41.symposia české anatomické společnosti s mezinárodní účastí}. Hradec Králové: Reklamní agentura Hradec Králové. s.~33-33. ISBN~80-239-1412-X. 2003.
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