We present a case of a 54-year-old woman who underwent a successful partial laparoscopic resection of a secondary inflamed esophageal duplication cyst localized in the lower posterior mediastinum. Laparoscopic approach was used for the surgical treatment of the intrathoracic esophageal duplication cyst for the first time. The standard surgical treatment uses thoracotomy or thoracoscopy, but the localization of the cyst in the lower mediastinum enables also the laparoscopic approach as it is demonstrated. Moreover, laparoscopy minimizes the risk of postoperative inflammatory complications in the pleural cavity especially after the surgery of secondary inflamed cysts.