J 2007

Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases

SALZMAN, Richard, Kateřina KAŇKOVÁ, Lukáš PÁCAL, Josef TOMANDL, Kateřina ŠÍROVÁ et. al.

Basic information

Original name

Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases

Name in Czech

Increased activity of superoxid dismutase in advanced stages of head and neck squamous cell carcinoma with locoregional metastases

Authors

SALZMAN, Richard (703 Slovakia, guarantor, belonging to the institution), Kateřina KAŇKOVÁ (203 Czech Republic, belonging to the institution), Lukáš PÁCAL (203 Czech Republic, belonging to the institution), Josef TOMANDL (203 Czech Republic, belonging to the institution), Kateřina ŠÍROVÁ (203 Czech Republic) and Rom KOSTŘICA (203 Czech Republic, belonging to the institution)

Edition

Neoplasma, Blarislava, Slovakia, Slovak Academy of Sciences, 2007, 0028-2685

Other information

Language

English

Type of outcome

Článek v odborném periodiku

Field of Study

30200 3.2 Clinical medicine

Country of publisher

Slovakia

Confidentiality degree

není předmětem státního či obchodního tajemství

Impact factor

Impact factor: 1.208

RIV identification code

RIV/00216224:14110/07:00019091

Organization unit

Faculty of Medicine

UT WoS

000251196300009

Keywords in English

antioxidative enzymes; head and neck cancer; metastasis; oxidative stress; polymorphism; syuperoxide dismutase

Tags

International impact, Reviewed
Změněno: 6/6/2012 08:39, doc. RNDr. Josef Tomandl, Ph.D.

Abstract

V originále

Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.

In Czech

Our results suggest that increased p-SOD at the time of the initial treatment for HNSCC is connected with a greater extent and nodal metastatic spread of the initial disease and an earlier disease relapse. Progression of diseases might be further modified by the presence of Ala/Ala genotype of the SOD2. Activity of p-SOD could thus offer diagnostic as well as prognostic value.

Links

NR7996, research and development project
Name: Polymorfismus antioxidativních enzymů ve vztahu ke krustózní tracheobronchitidě jako závažné komplikaci u tracheotomovaných pacientů
Investor: Ministry of Health of the CR